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ProteomicsIntegrative proteomics and transcriptomics of human T-cells reveals temporal changes in metabolic pathways following TCR-mediated activation
T-cells are a critical component of the adaptive immune system and play a key role in immunological surveillance. Upon engagement of T-cell receptor (TCR), CD4+ and CD8+ T-cells acquire effector functions through a complex interplay between mRNA and proteins yet to be fully understood. In this study...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD038810 | Pride
Human t cell activation Dda proteomics Cd8+ t cells Cd4+ t cells 
ModelsMukhopadhyay2013 - T cell receptor proximal signaling reveals emergent ultrasensitivity
Mukhopadhyay2013 - T cell receptor proximal signaling reveals emergent ultrasensitivity This model is described in the article: Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity. Mukhopadhyay H, Cordoba SP, Maini PK, van der Merwe PA, Dush...
2016-11-03 | MODEL1604100000 | BioModels
MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
UnknownCoexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity.
Not available
S-EPMC4705591 | biostudies-literature
UnknownImmunoglobulin Profile and Lymphocyte Subsets in Preterm Neonates.
Not available
S-EPMC8964378 | biostudies-literature
UnknownIntracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Not available
S-EPMC7613107 | biostudies-literature
UnknownViral diversity influences T-cell responses to enteric human adenoviruses F40 and F41.
Not available
S-EPMC12821363 | biostudies-literature
UnknownBerberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis.
Not available
S-EPMC9990925 | biostudies-literature
UnknownIntegrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation.
Not available
S-EPMC10901835 | biostudies-literature
UnknownSignatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy.
Not available
S-EPMC6238744 | biostudies-literature
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