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TranscriptomicsInositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients [Human arrays]
Elevated inositol trisphosphate receptor (IP3R) levels have been previously reported in skeletal muscle myotubes derived from patients with ryanodine receptor 1 (RyR1) mutation related core myopathies. However, the functional relevance and the relationship of IP3R mediated Ca2+ signalling with the p...
ORGANISM(S): Homo sapiens 
2020-09-15 | GSE103854 | GEO
TranscriptomicsInositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients [Mouse arrays]
Elevated inositol trisphosphate receptor (IP3R) levels have been previously reported in skeletal muscle myotubes derived from patients with ryanodine receptor 1 (RyR1) mutation related core myopathies. However, the functional relevance and the relationship of IP3R mediated Ca2+ signalling with the p...
ORGANISM(S): Mus musculus 
2020-09-15 | GSE103853 | GEO
TranscriptomicsThe immunoregulatory effect of macrophage-specific PPAR gamma deficiency on experimental inflammatory bowel disease
Inflammatory bowel disease (IBD) is a condition characterized by severe intestinal inflammation and immune cell activation. The severity of the disease can be mitigated by compounds which activate peroxisome proliferator-activated receptor gamma (PPAR gamma), a receptor present widely in tissues in...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-23421 | biostudies-arrayexpress
TranscriptomicsQuinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, Nuclear Factor-kappa B and Cell Cycle Progression in Non-Small Cell Lung Cancer
Erlotinib is a tyrosine kinase inhibitor (TKI) that is approved as a second-line monotherapy in patients with advanced non-small cell lung cancer (NSCLC). In these patients, erlotinib prolongs survival but its benefit remains modest since many tumors express wild-type EGF receptor (wtEGFR) lacking a...
ORGANISM(S): Homo sapiens 
2014-06-19 | E-GEOD-57422 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of multi-organ metastasis in the VO-PyMT mouse model of breast cancer
Metastasis frequently affects multiple organs in  stage IV breast cancer patients and is associated with dismal outcomes. The mechanisms enabling cancer cell colonization across diverse anatomical sites remain poorly understood, mainly due to lack of models of systemic disease and of studies in clin...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-16621 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of epithelial cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress
TranscriptomicsMetabolic exhaustion underlies sarcopenic obesity susceptibility in aging mice as revealed by multi-omics factor analysis
Sarcopenic obesity affects up to 40% of older adults with obesity, yet many remain protected despite comparable metabolic burden. The molecular basis for this heterogeneity remains unknown, limiting risk stratification and targeted intervention. We superimposed metabolic challenge on aging physiolog...
ORGANISM(S): Mus musculus 
2026-09-22 | E-MTAB-15944 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression levels in wild-type (Col-0), med18 and med25 mutant lines of Arabidopsis thaliana
Plants were grown in a mix (2:1) of soil and vermiculite in individual pots and cultivated in a growth chamber with 60-70% relative humidity and a day/night cycle (16hr-23°C/8h-20°C) at around 110 mol.m-2.s-1. For the microarray and metabolomic experiments, leaves of med18, med25, and WT were collec...
ORGANISM(S): Arabidopsis thaliana 
2017-09-29 | E-MTAB-5748 | biostudies-arrayexpress
UnknownStructure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils.
Not available
S-EPMC12262644 | biostudies-literature
ProteomicsSEPN1-related myopathy depends on the oxidoreductase ERO1 alpha and is druggable with the chemical chaperone TUDCA
SEPN1-related myopathy depends on the oxidoreductase ERO1 alpha and is druggable with the chemical chaperone TUDCA
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD047157 | Pride
Tudca Multi mini-core disease Er stress Ero1 Sepn1 Core myopathy 
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