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ProteomicsWithanolide analogues disrupt a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP (Expression proteomics)
Metabolic alterations in cancers precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of underexplored chemotypes. We identify W7, a synthetic withanolide analog with pronounced anti-leukemic ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD040694 | Pride
Thermal proteome profiling Expression proteomics Withanolides Natural product-inspired compound libraries 
ProteomicsIntegrated proteomics and transcriptomics analysis identifies novel cell surface markers of HIV latency
Background: The cellular reservoir of latent HIV infection remains the main barrier to cure this virus. Elimination of this reservoir would be possible, if molecular identity of latently infected cells were fully elucidated. Biomarkers proposed previously were able to capture only a relatively small...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024014 | Pride
Primary cd4+ t cells Transcriptome Plxnb2 Liquid chromatography mass spectrometry Ceacam1 Hiv latency Biomarkers Proteome Rna-seq 
TranscriptomicsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Techn...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-49507 | biostudies-arrayexpress
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes (miRNA data)
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7892 | biostudies-arrayexpress
UnknownGlycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica.
Not available
S-EPMC10755494 | biostudies-literature
ProteomicsMulti-omics reveals the lipid inventory of synaptic junctions and altered lipid signaling in environmental enrichment
Membrane lipids are essential components of synaptic junctions that have key functions in neurotransmission. In the first part of the study, we provide a quantitative lipid inventory of mouse and rat synaptic junctions. We next used a simultaneous multi-omics extraction and analysis workflow termed ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2023-11-14 | PXD017997 | Pride
Enriched environment Lipidomics Multi-omics Endocannabinoid signaling Synaptic junctions 
UnknownInteraction of Fluorescently Labeled Cadherin G Protein-coupled Receptor with the Cry1Ab Toxin of Bacillus thuringiensis.
Not available
S-EPMC6049086 | biostudies-literature
ProteomicsWithanolide analogues disrupt a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP (TPP)
Metabolic alterations in cancers precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of underexplored chemotypes. We identify W7, a synthetic withanolide analog with pronounced anti-leukemic ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD040692 | Pride
Thermal proteome profiling Expression proteomics Withanolides Natural product-inspired compound libraries 
ProteomicsInterBatch Benchmarking Experiment for Isobaric Proteomics
We developed a unique multi-batch benchmarking dataset. The design is based on a standard two-species dilution model3,18,19 with mouse plasma used to create a background of potentially interfering peptides at 1:1 ratios while yeast cultures are mixed across a range of known ratios. For the purpose...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2024-03-18 | PXD036799 | Pride
Isobaric Yeast Two-species interference model Mouse Tmt 
UnknownIntegrating proteomics and metabolomics to evaluate impact of semen collection techniques on the quality and cryotolerance of goat semen.
Not available
S-EPMC11603158 | biostudies-literature
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