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TranscriptomicsDefective structural RNA processing in relapsing-remitting multiple sclerosis
It is fundamentally unknown how normal cellular processes or responses to extracellular stimuli may invoke polyadenylation and degradation of ncRNA substrates or if human disease processes exhibit defects in polyadenylation of ncRNA substrates as part of their pathogenesis. Our results demonstrate t...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66573 | biostudies-arrayexpress
TranscriptomicsA chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.
Injury to the central nervous system (CNS) may result in lifelong loss of function due, in part, to the regenerative failure of CNS neurons. Major barriers to regeneration faced by injured CNS neurons include inhibitory proteins derived from myelin and the astroglial scar. Previously, we described...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-34331 | biostudies-arrayexpress
ProteomicsIdentification of ABL Kinase Substrates by Kinase Assay Linked Phosphoproteomics and Multiple Drug Treatments
The kinase assay linked phosphoproteomics (KALIP) strategy was used to identify direct substrates of the Abelson tyrosine kinase (ABL). First, kinase assays using peptides and proteins from chronic myelogenous leukemia cells and recombinant ABL were done to identify kinase substrates in vitro. The A...
ORGANISM(S): Homo Sapiens (human) 
2019-03-20 | PXD005431 | JPOST Repository
TranscriptomicsArrayCGH profiling of two B-cell lineage subpopulations in multiple myeloma
ArrayCGH profiling and examination of IgH disruption by FISH on two myeloma B-cell lineage subpopulations: CD138+ and CD19+ to confirm existence of abnormal bone marrow B-cell subset contaning genetic background for primary oncogenic events.
ORGANISM(S): Homo sapiens 
2013-12-07 | E-MTAB-1401 | biostudies-arrayexpress
TranscriptomicsClonal cytogenetics changes in progression of multiple myeloma to extramedullary relapse and plasmocellular leukemia – case report
Extramedullary relapse (EM) of multiple myeloma (MM) is defined as infiltration of plasma cells (PC) outside of the bone marrow. EM is an aggressive form of the disease with a dismal outcome. We present cytogenetic findings of a 52-year-old female patient who was diagnosed with MM in 2008 and progr...
ORGANISM(S): Homo sapiens 
2015-10-10 | E-MTAB-3577 | biostudies-arrayexpress
ProteomicsProteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity
Deubiquitylating enzymes (DUBs) counteract ubiquitylation to control stability or activity of substrates. Identification of DUB substrates is challenging because multiple DUBs can act on the same substrate, thwarting genetic approaches. Here, we circumvent redundancy by chemically inhibiting multipl...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-09-02 | PXD022762 | Pride
Xenopus Dub Sps-ms3 Ubiquitin 
ProteomicsProteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity
Deubiquitylating enzymes (DUBs) counteract ubiquitylation to control stability or activity of substrates. Identification of DUB substrates is challenging because multiple DUBs can act on the same substrate, thwarting genetic approaches. Here, we circumvent redundancy by chemically inhibiting multipl...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-09-09 | PXD022740 | Pride
Xenopus Dub Sps-ms3 Ubiquitin 
ProteomicsTRIM21 enhances bortezomib sensitivity in multiple myeloma by halting pro-survival autophagy
Bortezomib (bort) is an effective therapeutic agent for multiple myeloma (MM) patients; however, the majority of patients develop drug resistance. Autophagy, a highly conserved process that recycles cytosol or entire organelles via lysosomal activity, is essential for the survival, homeostasis and d...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042004 | Pride
Trim21 multiple myeloma bortezomib 
TranscriptomicsPostia placenta gene expression on different substrates
Using whole genome microarrays based on the annotated genomes of Postia placenta, we monitored the changes in its transcriptomes relevant to cell wall degradation during growth on three chemically distinct Populus trichocarpa (poplar) wood substrates. The research goal is to identtify genes essentia...
ORGANISM(S): Postia placenta 
2015-05-19 | E-GEOD-69004 | biostudies-arrayexpress
TranscriptomicsPhanerochaete chrysosporium gene expression on different substrates
Using whole genome microarrays based on the annotated genomes of Phanerochaete chrysosporium, we monitored the changes in its transcriptomes relevant to cell wall degradation during growth on three chemically distinct Populus trichocarpa (poplar) wood substrates. Results of this study are sumbitted ...
ORGANISM(S): Phanerochaete chrysosporium 
2015-05-19 | E-GEOD-69008 | biostudies-arrayexpress
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