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ProteomicsERK inhibits Cic repressor function via multisite phosphorylation
The receptor tyrosine kinase (RTK)/Extracellular Signal-Regulated Kinase (ERK) signaling pathway controls cell proliferation, differentiation, and survival. How ERK activation is relayed to its phosphorylation targets is not well understood. The transcriptional repressor Capicua (Cic) has emerged as...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-03-16 | PXD066179 | Pride
Erk Multisite phosphorylation Capicua Drosophila 
ModelsThomson2009 – Unlimited multistability in multisite phosphorylation systems
This model describes a distributive, sequential system with n = 4, which is a simplified example of unlimited multistability in multisite phosphorylation systems. This method can be applied to systems with multiple substrates and enzymes. This model is described in the article: Unlimited multistabil...
2020-02-12 | MODEL2002110001 | BioModels
ModelsMarkevich2004 - MAPK double phosphorylation, ordered Michaelis-Menton
Markevich2004 - MAPK double phosphorylation, ordered Michaelis-Menton The model corresponds to the schemas 1 and 2 of Markevich et al 2004, as described in the figure 1 and modelled using Michaelis-Menten like kinetics. Phosphorylations and dephosphorylations follow distributive ordered kinetics. It...
2024-09-02 | BIOMD0000000027 | BioModels
ModelsOrtega2006 - bistability from double phosphorylation in signal transduction
Ortega2006 - bistability from double phosphorylation in signal transduction This model is described in the article: Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. Ortega F, Ga...
2024-09-02 | BIOMD0000000258 | BioModels
ProteomicsMultisite phosphorylation of intrinsically disordered region of DVL
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD063926 | Pride
Dishevelled Endogenous Phosphorylation 
ProteomicsMultisite phosphorylation of intrinsically disordered region of DVL
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD063852 | Pride
Dishevelled Phosphorylation 
UnknownMultisite phosphorylation code of CDK.
Not available
S-EPMC6614033 | biostudies-literature
ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
UnknownLong-term dynamics of multisite phosphorylation.
Not available
S-EPMC4945148 | biostudies-literature
UnknownA mathematical model of multisite phosphorylation of tau protein.
Not available
S-EPMC5800643 | biostudies-literature
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