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TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsRole of Capicua in metabolic system
CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified criti...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-60375 | biostudies-arrayexpress
UnknownInactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma.
Not available
S-EPMC7305345 | biostudies-literature
ProteomicsGlobal phosphoproteomics elicited by the SCF/KIT axis in human skin mast cells unveil capicua as a potent KIT repressor
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD028252 | Pride
Phosphoproteome Human Scf Mast cells 
UnknownA MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
Not available
S-EPMC1794389 | biostudies-literature
UnknownInactivation of Capicua drives cancer metastasis.
Not available
S-EPMC5195898 | biostudies-literature
UnknownCapicua is a fast-acting transcriptional brake.
Not available
S-EPMC8612007 | biostudies-literature
ProteomicsERK inhibits Cic repressor function via multisite phosphorylation
The receptor tyrosine kinase (RTK)/Extracellular Signal-Regulated Kinase (ERK) signaling pathway controls cell proliferation, differentiation, and survival. How ERK activation is relayed to its phosphorylation targets is not well understood. The transcriptional repressor Capicua (Cic) has emerged as...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-03-16 | PXD066179 | Pride
Erk Multisite phosphorylation Capicua Drosophila 
UnknownRapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua.
Not available
S-EPMC7161736 | biostudies-literature
GenomicsFunctional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease
Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease
PRJNA1366358 | ENA
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