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TranscriptomicsTranscriptome Profiling and Sequencing of differentiated Human Hematopoietic Stem cells Reveal Lineage Specific Expression and Alternative Splicing of Genes
Hematopoietic differentiation is strictly regulated by complex network of transcription factors that are controlled by ligands binding to cell surface receptors. Disruptions of the intricate sequences of transcriptional activation and suppression of multiple genes cause hematological diseases, such...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-29989 | biostudies-arrayexpress
TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
UnknownTranscriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes.
Not available
S-EPMC3217327 | biostudies-literature
TranscriptomicsGenome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors
Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cel...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
UnknownA characterization of the oral microbiome in allogeneic stem cell transplant patients.
Not available
S-EPMC3483166 | biostudies-literature
TranscriptomicsCooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24869 | biostudies-arrayexpress
UnknowncGMP-independent nitric oxide signaling and regulation of the cell cycle.
Not available
S-EPMC1312313 | biostudies-literature
UnknownElucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease.
Not available
S-EPMC9664436 | biostudies-literature
UnknownDissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.
Not available
S-EPMC4376567 | biostudies-literature
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