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MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
TranscriptomicsAngiogenesis gene expression upon Notch activation in human vascular smooth muscle cells
VSMCs were cultured on Jag1 or IgG-coated plates as described above. RNA was extracted using RNA isolation kit (Qiagen). Reverse-transcription PCR was done with RNA-to-cDNA kit (Applied Biosystems). cDNA was run on a TaqMan Low-Density Array, human angiogenesis panel (Applied Biosystems , Cat#437872...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-34024 | biostudies-arrayexpress
UnknownSafety and Effectiveness of Repeat Treatment With VYC-15L for Lip and Perioral Enhancement: Results From a Prospective Multicenter Study.
Not available
S-EPMC6416707 | biostudies-literature
ProteomicsUnstable Atherosclerotic Plaque Proteome
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, is a major health burden worldwide. Limited understanding as to the molecular drivers of plaque instability and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Utilisin...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD030857 | Pride
Atherosclerosis Therapeutic Mouse Plaque Proteome 
ProteomicsMulti-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, are a major health concern worldwide. Limited understanding as to the molecular drivers of plaque destabilisation and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Us...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-24 | PXD018224 | Pride
Atherosclerosis Mouse Plaque Thrombosis 
ProteomicsTEFM variants impair mitochondrial transcription elongation causing childhood-onset neurological disease
Mutations in either the mitochondrial or nuclear genomes are associated with a diverse group of human disorders characterized by impaired mitochondrial respiration. Within this group, an increasing number of mutations have been identified in nuclear genes involved in mitochondrial RNA biology. The T...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD030427 | Pride
Mitochondria Transcription Mitochondrial disease Rna 
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
MetabolomicsMass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with 50-80% patients exhibiting mutations in the von Hippel-Lindau (VHL) gene. RSUME (RWD domain (termed after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)...
2021-10-06 | MTBLS1935 | MetaboLights
UnknownRefining epigenetic prediction of chronological and biological age.
Not available
S-EPMC9976489 | biostudies-literature
UnknownEtomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.
Not available
S-EPMC6125190 | biostudies-literature
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