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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
MetabolomicsHigh-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis

Circulating palmitic acid (PA) is generally considered to be provided from diets and endogenous synthesis, and is adversely correlated with cardiovascular disease (CVD). It is unknown, however, if gut microbiota modulates circulating PA and potentiate CVD risk. Here we demonstrate that in CVD pat...

2025-06-20 | MTBLS12618 | MetaboLights
Metabolomics1D-1H-Nuclear Magnetic Resonance Metabolomics Reveals Age-related Changes in Metabolites Associated with Experimental Venous Thrombosis
Not available
ORGANISM(S): Mus musculus 
ST000607 | MetabolomicsWorkbench
TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
ProteomicsAbsence of COVID-19-associated Changes in Coagulation and Thrombosis in the Ferret Model
Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study ven...
ORGANISM(S): Homo sapiens (Human) Mustela putorius furo (European domestic ferret) (Mustela furo) 
2022-07-19 | PXD027582 | Pride
Covid-19 Mass spectrometry Ferrets Thrombosis Proteomics 
ProteomicsLymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs
In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigated t...
ORGANISM(S): Rattus Norvegicus 
PXD056584 |
UnknownNeeds and challenges among physicians and researchers in thrombosis and hemostasis: Results from an international study.
Not available
S-EPMC6781915 | biostudies-literature
UnknownAbsence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model.
Not available
S-EPMC8690567 | biostudies-literature
UnknownThe intersection of protein disulfide isomerase and cancer associated thrombosis.
Not available
S-EPMC5929485 | biostudies-literature
GenomicsPrevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger
Prevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger
PRJNA1322289 | ENA
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