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TranscriptomicsLungs of ferrets infected with either an H3N2 or H5N1 subtype of influenza A virus.
A global genomics approach was used to identify patterns of immune dysregulation during H5N1 influenza virus infection as the host response, in particular hyperchemokinemia, is thought to contribute to the extreme pathology associated with this disease. Keywords: time course Ferrets were inoculated ...
ORGANISM(S): Mustela putorius furo 
2010-05-15 | E-GEOD-9606 | biostudies-arrayexpress
TranscriptomicsEarly gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we inve...
ORGANISM(S): Mustela putorius furo 
2010-12-01 | E-GEOD-22581 | biostudies-arrayexpress
ProteomicsAcute experimental infection of bats and ferrets with Hendra virus: insights into the early host response of the reservoir host and susceptible model species
Bats are the natural reservoir host for a number of zoonotic viruses, including Hendra virus (HeV) which causes severe clinical disease in humans and other susceptible hosts. Our understanding of the ability of bats to avoid clinical disease following infection with viruses such as HeV has come pred...
ORGANISM(S): Pteropus alecto (Black flying fox) Mustela putorius furo (European domestic ferret) (Mustela furo) 
2020-03-03 | PXD017495 | Pride
Proteomics Bat Ferret Hendra virus Lung Immune response Lc-ms/ms 
TranscriptomicsAbsence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge
To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy,...
ORGANISM(S): Mustela putorius furo 
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in lymph nodes from ferrets infected with A/California/07/2009
Pandemic H1N1 influenza A Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but significant number of infected individuals. Microarray analysis of the lymph nodes from ferrets infected with A/California/07/2009 shows intense gene u...
ORGANISM(S): Mustela putorius furo 
2013-01-28 | E-GEOD-36019 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus
The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG...
ORGANISM(S): Mustela putorius furo 
2011-02-11 | E-GEOD-27248 | biostudies-arrayexpress
TranscriptomicsEarly CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
2010-04-12 | E-GEOD-17079 | biostudies-arrayexpress
ProteomicsAbsence of COVID-19-associated Changes in Coagulation and Thrombosis in the Ferret Model
Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study ven...
ORGANISM(S): Homo sapiens (Human) Mustela putorius furo (European domestic ferret) (Mustela furo) 
2022-07-19 | PXD027582 | Pride
Covid-19 Mass spectrometry Ferrets Thrombosis Proteomics 
TranscriptomicsIF002 - Custom designed Agilent arrays result on the Cystic Fibrosis model in ferrets.
The goal of this study is to use newly designed ferret Agilent arrays to compare transcriptome profiles between wild type, CF3959(-/-) and CF3959(+/-) ferrets. Lung and trachea tissues from newborn and 15 day-old ferrets were RNA-extracted and subsequently analyzed by microarray. Using the newly de...
ORGANISM(S): Mustela putorius furo 
2014-07-18 | E-GEOD-49061 | biostudies-arrayexpress
TranscriptomicsHost Gene Expression Signatures Discriminate between Ferrets Infected with Genetically Similar H1N1 Strains.
Different respiratory viruses induce virus-specific gene expression in the host. Recent evidence, including those presented here, suggests that genetically related isolates of influenza virus induce strain specific host gene regulation in several animal models. Here, we identified systemic strain-sp...
ORGANISM(S): Mustela putorius furo 
2012-06-15 | E-GEOD-28967 | biostudies-arrayexpress
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