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MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
ProteomicsDIA proteomic analysis of unstimulated murine bone marrow derived macrophages from WT, Nrf2 KO and Keap1 KD cells
Unstimulated murine bone marrow derived macrophages cultured in L92 media from WT (4 biological replicates), Nrf2 KO (3 biological replicates) and Keap1 KD BMDM (3 biological replicates) were processed and analysed utilising DIA (label free) proteomic analysis. The Nrf2 KO mouse (DOI: 10.1006/bbrc.1...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD030455 | Pride
Dia Keap1 Nrf2 Macrophages Bmdm Murine 
ProteomicsNrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved networks of cytoprotective proteins controlled by transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator the Kelch-like ECH associated protein 1 (Keap1). Here, we used h...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-13 | PXD027737 | Pride
Tmt Keap1 Nrf2 Mitochondria Bmdm Murine 
UnknownPro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation.
Not available
S-EPMC11946910 | biostudies-literature
UnknownNrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Not available
S-EPMC8844662 | biostudies-literature
ProteomicsExplorining the effect of LPS treatment on mouse macrophages
Proteomic assessment of mouse macrophages treated with LPS for 24 h.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD029155 | Pride
Mouse macrophage lps 
UnknownItaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Not available
S-EPMC6047741 | biostudies-literature
UnknownImplementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.
Not available
S-EPMC10751594 | biostudies-literature
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
UnknownGene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
Not available
S-EPMC5379914 | biostudies-literature
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