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MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
TranscriptomicsHoxd genes and fiber type-specific markers specify adult mouse muscle type in a diet-independent way
Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are ident...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-18127 | biostudies-arrayexpress
MetabolomicsMulti-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
ProteomicsSingle muscle fiber proteomics reveals fiber type-specific features of human muscle aging
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...
ORGANISM(S): Homo sapiens (Human) 
2017-06-14 | PXD006182 | Pride
Muscle fibers Skeletal muscle Aging 
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsAberrant calcium influx causes fiber type shift and mitochondrial loss in skeletal muscle
Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact alternative splicing of the voltage-gated calcium channel CaV1.1 actively suppresses calcium currents in mature muscle. Why this might be necessary is not known. However, splicing defects causing aberrant ...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-67803 | biostudies-arrayexpress
ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
ProteomicsFiber type-specific proteomic alterations in R349P desminopathy mice
Desminopathies refer to a group of rare human myopathies and cardiomyopathies, caused by mutations in the desmin gene. So far, there is no causative treatment and little is known about early pathological effects, since alterations in muscle biopsies usually reflect late stages of the disease. Thus, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD049207 | Pride
Myofibrillar myopathy Desmin Proteomics Fiber types 
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
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