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ProteomicsMUSCLE-DERIVED GALECTIN 3 IS A NEW MEDIATOR OF MUSCLE TO BONE CROSSTALK
Galectin-3 is a pleiotropic lectin that regulates multiple cellular processes in a multitude of tissue types. In bone, depending on its cellular localization, Galectin 3 has a dual and opposite role, as if on the one hand intracellular Galectin 3 promotes bone formation, on the other circulating Gal...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040187 | Pride
Muscle to bone crosstalk Galectin 3 Proteomics Bone remodeling 
ProteomicsMuscle-derived extracellular vesicles transport glycolysis enzyme to mediate muscle-to-bone crosstalk
Identification of cues from skeletal muscle that control bone formation is essential for understanding the crosstalk between muscle and bone and for developing novel therapeutics for degenerative bone diseases. Here, we identified that skeletal muscle secreted abundant extracellular vesicles (Mu-EVs...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-19 | PXD043785 | Pride
Bone marrow mesenchymal stem/stromal cells Glycolysis enzyme Aerobic glycolysis  lactate dehydrogenase a Skeletal muscle Extracellular vesicles 
ProteomicsMuscle-derived extracellular vesicles transport glycolysis enzyme to mediate muscle-to-bone crosstalk
Identification of cues from skeletal muscle that control bone formation is essential for understanding the crosstalk between muscle and bone and for developing novel therapeutics for degenerative bone diseases. Here, we identified that skeletal muscle secreted abundant extracellular vesicles (Mu-EVs...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-19 | PXD040363 | Pride
Skeletal muscle extracellular vesicles glycolysis 
ProteomicsLGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance
Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. We screened the secretome and receptome in Drosophila to identify the hormona...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD053061 | Pride
Phosphoproteomics Muscle-adipose tissue crosstalk Lgr Insulin resistance T2d 
UnknownSkeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8<sup>+</sup> T cell-secreted CCL5.
Not available
S-EPMC12661402 | biostudies-literature
UnknownWnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review.
Not available
S-EPMC11245956 | biostudies-literature
ProteomicsSIRT3-Enriched Small Extracellular Vesicles Provide a Means for Skeletal Muscle-Bone crosstalk during Exercise
Endurance exercise (Exe) has shown reliable protective effects against bone loss in the elderly and postmenopausal women. However, the mechanisms underlying Exe-mediated muscle-bone crosstalk remain to be fully elucidated. Here, we demonstrated that Exe enhanced the secretion of skeletal muscle-deri...
ORGANISM(S): Mus Musculus 
2026-09-22 | PXD084620 |
UnknownIdentification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk.
Not available
S-EPMC7828203 | biostudies-literature
UnknownBone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2.
Not available
S-EPMC5111231 | biostudies-literature
UnknownNew Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse.
Not available
S-EPMC7431610 | biostudies-literature
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