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TranscriptomicsChromatin immunopreciptiation of human breast epithelial HME1 cell lines over-expressing wild type or mutant p53 to study p53 binding
p53 binding was studied using ChIP on chip technique in breast epithelial HME1 cell lines overexpressing wt or mutant p53
ORGANISM(S): Homo sapiens 
2008-10-25 | E-MEXP-1491 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
GenomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions
p53 wildtype or complementing DNA binding cooperativity versions (EE, RR, EE/RR) were overexpressed in SAOS cells and 18h later harvested to perform ChIP with an p53-specific antibody. The enriched DNA fragments were purified and identified by high throughput sequencing.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1394 | biostudies-arrayexpress
GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance
This SuperSeries is composed of the following subset Series: GSE36749: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq] GSE36751: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36752 | biostudies-arrayexpress
TranscriptomicsPin1/mutant-p53 jointly controlled genes
To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells. MDA-MB-231 cells were transfected twice with siRNA agains...
ORGANISM(S): Homo sapiens 
2011-05-30 | E-GEOD-26262 | biostudies-arrayexpress
TranscriptomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions - Expression profiling
P53 wildtype or complementing DNA binding cooperativity versions (p53EE, p53RR, p53EE/RR) were overexpressed in SAOS cells. After 18h cells were harvested and subjected to expression profiling.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1403 | biostudies-arrayexpress
GenomicsBRD7 is a candidate tumour suppressor gene required for p53 function
Oncogene-induced senescence (OIS) is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations while others show a dysfunctional p53 pathway, frequently by unknown mechanisms. We identified BRD7, a bromodomain-containing protein whos...
ORGANISM(S): Homo sapiens 
2010-03-14 | E-GEOD-20076 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human p53+ and p53- fibroblasts treated with arsenite reveals exit from arsenite-induced mitotic arrest is p53 dependent
Microarray data from G2-synchronized p53(+) and p53(-) fibroblasts before and after 3 h release from cell cycle blockade in the presence of 5 uM sodium arsenite. Experiment Overall Design: Cells expressing p53 from a tet-off regulated construct were synchronized in G2 with a two-step procedure using...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-7101 | biostudies-arrayexpress
ProteomicsMutant p53 interactome study with IP-MS
Inactivating TP53 mutations lead to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promote tumor development and progression. The GOF activities of TP53 mutations are well documented, but the mechanisms involved remain p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD047094 | Pride
Ms Ip Mutant p53 P53 
TranscriptomicsInfluence of human P53 on plant gene expression
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis an...
ORGANISM(S): Arabidopsis thaliana 
2016-06-26 | E-GEOD-79678 | biostudies-arrayexpress
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