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MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
GenomicsDifferential expression of keratin and keratin associated proteins in spontaneously mutated mice
Differential expression of keratin and keratin associated proteins in spontaneously mutated mice
PRJNA911295 | ENA
TranscriptomicsThe RALA pathway can maintain the proliferation of KRAS- and BRAF-mutated cancer cells
By silencing of RALA, a downstream member of the RAS signal transduction pathway, we aimed to determine whether genes downstream of a mutated KRAS (codon 12 or 13) or a mutated BRAF can have significant functions in colorectal cancer carcinogenesis. RALA was silenced in three colorectal cancer cell ...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-GEOD-39857 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in ATM-deficient MEFs
The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs. Nonirradiated-ATM-WT vs Irradiated-ATM-WT vs Nonirradaited-ATM-KO vs IrradiatedATM-KO
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23116 | biostudies-arrayexpress
ProteomicsPhosphoproteomics analysis of normal and mutated granulocyte colony stimulating factor receptors
Granulocyte colony stimulating factor receptor (G-CSFR) plays important role in the production of neutrophils from hematopoietic stem cells. Mutated form of the receptor has been directly associated with two distinct malignant phenotype in patients, e.g. acute myeloid leukemia (AML) and chronic neut...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-14 | PXD009311 | Pride
Phosphoproteomics Silac G-csfr signaling 
TranscriptomicsAnalysis of transcriptional response to mutated Potyvirus Potato virus A that induces necrotic symptoms.
Mutations introduced to a highly variable region in HCpro reduced HCpro-HIP2 interactions and virulence of PVA, and induced novel types of necrotic symptoms in the systemically infected leaves of Nicotiana species. Microarray-based analysis of gene expression revealed induction of large numbers of d...
ORGANISM(S): Nicotiana tabacum 
2013-03-23 | E-GEOD-42833 | biostudies-arrayexpress
TranscriptomicsExpression data from intestine of HDAC1 and HDAC2 conditionally mutated mice
Acetylation and deacetylation of histones and other proteins depend on the opposing activities of histone acetyltransferases and histone deacetylases (HDACs), leading to either positive or negative gene expression changes. The use of HDAC inhibitors (HDACi) has uncovered a role for HDACs in the cont...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-47745 | biostudies-arrayexpress
TranscriptomicsRECURRENT SETBP1 MUTATIONS IN ATYPICAL CHRONIC MYELOID LEUKEMIA
RNA-Seq analysis of atypical chronic myeloid leukemia samples We sequenced leukemic mRNA from 13 Atypical Cronic Mieloid Leukemia (aCML) samples by Illumina GAIIx. Transcriptomic profiles, differentially expressed genes and pathway enrichment analysis were obtained comparing 7 SETBP1-mutated sample...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42146 | biostudies-arrayexpress
TranscriptomicsA putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. An experimental purification in which a presumed RNA binding protein was used for an RNA immunoprecipitation and microarray analysis (RIP-CHIP). Total cell extracts w...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-16942 | biostudies-arrayexpress
ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
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