Mycobacterium smegmatis

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Unknown (1577)
Genomics (235)
Transcriptomics (146)
Proteomics (93)
Metabolomics (8)
Other (7)

Organisms

Mycolicibacterium smegmatis (58)
Mycolicibacterium smegmatis MC2 155 (46)
Mycobacterium tuberculosis (14)
Mycobacterium tuberculosis H37Rv (11)
Mus musculus (10)
Mycobacterium avium subsp. paratuberculosis (4)
Homo sapiens (4)
Mycolicibacterium smegmatis MC2 51 (3)
Mycobacterium phage Butters (2)
Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 (2)
Mycobacterium phage Giles (1)
Mycobacterium phage Kampy (1)
Mycobacterium phage Xeno (1)
Mycobacterium phage Panchino (1)
Mycobacterium phage Xerxes (1)
Mycobacterium phage Redi (1)
Mycobacterium phage Phrann (1)
Mycobacterium phage MichelleMyBell (1)
Mycobacterium phage Charlie (1)
Mycobacterium tuberculosis variant bovis (1)
Mycobacterium avium subsp. paratuberculosis K-10 (1)
Mycobacterium tuberculosis H37Ra (1)
Mycobacterium phage Island3 (1)
Bacillus subtilis (1)
Danio rerio (1)
Mycobacterium tuberculosis variant bovis BCG (1)
Mycobacterium tuberculosis variant bovis BCG str. China (1)
Mycobacterium tuberculosis variant bovis BCG str. Frappier (1)
Mycobacterium tuberculosis variant bovis BCG str. Glaxo (1)
Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P (1)

Organisms

Mycolicibacterium smegmatis (61)
Mycolicibacterium smegmatis MC2 155 (27)
Mus musculus (6)
Mycolicibacterium smegmatis MKD8 (2)
Mycobacterium tuberculosis (2)
Homo sapiens (2)
Streptomyces sp. MBRL 10 (1)
Mycobacterium sp. JS623 (1)
Mycolicibacterium smegmatis MC2 51 (1)
Mycobacterium tuberculosis H37Ra (1)
Mycobacterium smegmatis phage (1)
Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 (1)
Mycobacterium Phage WST1 (1)
Caudoviricetes (1)
Mycobacterium (1)
Bacillus subtilis (1)
Danio rerio (1)
unidentified (1)

Repository

ENA (223)
geo (92)
biostudies-arrayexpress (72)
pride (69)
MassIVE (11)
iProX (9)
GNPS (4)
MetaboLights (4)
jPOST (2)
PAXDB (2)
PanoramaPublic (1)

Tissue

Cell culture (10)
Cell suspension culture (2)
Prokaryotic cell (2)
Bone marrow (1)
Cell line cell (1)
Dendritic cell (1)
Permanent cell line cell (1)
Primary cell (1)

Disease

Tuberculosis (10)
Pulmonary tuberculosis (2)
Disease free (1)

Technology Type

Mass Spectrometry (69)
Shotgun proteomics (45)
Bottom-up proteomics (13)
Data-dependent acquisition (6)
Affinity purification coupled with mass spectrometry proteomics (4)
Gel-based experiment (4)
Mass spectrometry (3)
Top-down proteomics (3)
Data-independent acquisition (2)
Mass spectrometry assay (1)
All-ion fragmentation (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
SWATH MS (1)

Instrument Platform

NextSeq 550 (7)
Q Exactive (6)
Illumina HiSeq 2000 (4)
NextSeq 500 (4)
Illumina MiSeq (2)
Illumina HiSeq 1500 (2)
Liquid Chromatography Tandem MS (LC-MS/MS) (2)
Orbitrap Eclipse (2)
Liquid Chromatography MS - positive - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)
Retsch MM400 (1)
Ion Torrent PGM (1)
NextSeq 2000 (1)
Illumina HiSeq 2500 (1)
Agilent 6550 QTOF (1)
TripleTOF 6600 (1)
ACQUITY UPLC I-Class (1)
LTQ Orbitrap (1)
Q Exactive HF-X (1)
SYNAPT G2-Si (1)
TimsTOF Pro 2 (1)
Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - alternating - hilic (1)
QSTAR XL (1)

Publication Date

2023 (21)
2011 (21)
2022 (21)
2021 (21)
2019 (18)
2024 (17)
2018 (17)
2025 (16)
2013 (15)
2015 (13)
2016 (12)
2012 (12)
2026 (11)
2020 (11)
2010 (10)
2017 (7)
2014 (6)
2009 (5)
2007 (4)

UNIPROT ID/AC

246196.MSMEI_0054 (2)
246196.MSMEI_0075 (2)
246196.MSMEI_0389 (2)
246196.MSMEI_0784 (2)
246196.MSMEI_0974 (2)
246196.MSMEI_1000 (2)
246196.MSMEI_1011 (2)
246196.MSMEI_1026 (2)
246196.MSMEI_1198 (2)
246196.MSMEI_1222 (2)
246196.MSMEI_1367 (2)
246196.MSMEI_1680 (2)
246196.MSMEI_1690 (2)
246196.MSMEI_1744 (2)
246196.MSMEI_1958 (2)
246196.MSMEI_2108 (2)
246196.MSMEI_2225 (2)
246196.MSMEI_2227 (2)
246196.MSMEI_2228 (2)
246196.MSMEI_2231 (2)
246196.MSMEI_2232 (2)
246196.MSMEI_2233 (2)
246196.MSMEI_2235 (2)
246196.MSMEI_2236 (2)
246196.MSMEI_2237 (2)
246196.MSMEI_2238 (2)
246196.MSMEI_2239 (2)
246196.MSMEI_2241 (2)
246196.MSMEI_2244 (2)
246196.MSMEI_2248 (2)

CHEBI ID

CHEBI:15781 (2)
CHEBI:134344 (1)
CHEBI:174826 (1)
CHEBI:44147 (1)
CHEBI:134607 (1)
CHEBI:87225 (1)
CHEBI:173359 (1)
CHEBI:16374 (1)
CHEBI:75245 (1)
CHEBI:169174 (1)
CHEBI:29063 (1)
CHEBI:192171 (1)
CHEBI:89881 (1)
CHEBI:47833 (1)
CHEBI:191608 (1)
CHEBI:176731 (1)
CHEBI:178694 (1)
CHEBI:173800 (1)
CHEBI:176734 (1)
CHEBI:89241 (1)
CHEBI:177805 (1)
CHEBI:89198 (1)
CHEBI:77127 (1)
CHEBI:168796 (1)
CHEBI:90066 (1)
CHEBI:193685 (1)
CHEBI:142659 (1)
CHEBI:173959 (1)
CHEBI:145972 (1)
CHEBI:176720 (1)

Metabolite Name

Mycothiol (1)
Ergothioneine(1+) (1)
N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine (1)
(5alpha,10beta)-6-Allylergoline-8-carboxylic acid (1)
3-Oxodocosanoic acid (1)
MK-9 (1)
MK-9 (H2) (1)
N-[(15Z)-tetracosenoyl]sphinganine-1-phosphocholine (1)
1-icosanoyl-2-[(5Z,8Z,11ZZ,14Z,17Z)-eicosapentaenoyl]-sn-glycerol (1)
OD2400000 (N-Lactoyl ethanolamine) (1)
O,o'-bis(trimethylsilyl)uracil (1)
1,2,3-Trimyristoleoyl Glycerol (1)
1-O-octadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine (1)
LV1850000 (1)
Adrenaline (1)
(+/-)-Metanephrine (1)
ACETYL PROLINE (1)
Urs-12-en-3-one (1)
Methionine S-oxide (1)
Prostaglandin F2alpha isopropyl ester (1)
5-[(9Z)-9-Hexadecenoyloxy]hexadecanoic acid (1)
Lys-thr (1)
1-hexadecanoyl-2-[(15Z)-tetracosenoyl]-sn-glycero-3-phosphocholine (1)
L-(+)-ERGOTHIONEINE (1)
N-[(13Z,16Z)-3-hydroxydocosa-13,16-enoyl]sphingosine-1-phosphocholine (1)
3-Hydroxy-3'-oxo-beta,epsilon-carotene (1)
2-(12-Tridecen-1-yl)furan (1)
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-yl acetate (1)
TG(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))[iso3] (1)
3-[(10Z)-10-Heptadecen-1-yl]phenol (1)

First Public Date

2024 (29)
2023 (24)
2014 (24)
2022 (20)
2025 (18)
2021 (18)
2026 (17)
2020 (16)
2019 (14)
2018 (13)
2013 (10)
2015 (9)
2016 (6)
2017 (5)

Classification

bacteria (6)
viruses (3)

Modification

Not available (1)

Study type

Transcription profiling by array (43)
RNA-seq of coding RNA (12)
ChIP-seq (7)
RIP-seq (3)
Other (2)
RNA-seq of total RNA (2)
Unknown experiment type (1)
ChIP-chip by tiling array (1)
Ribo-seq (1)

Release Date

2020 (127)
2021 (115)
2023 (112)
2022 (110)
2024 (109)
2019 (105)
2018 (99)
2017 (97)
2025 (94)
2015 (82)
2016 (80)
2012 (72)
2013 (70)
2014 (62)
2011 (56)
2010 (42)
2009 (38)
2008 (34)
2007 (19)
2005 (19)
2006 (18)
1998 (16)
2003 (15)
2001 (11)
1999 (11)
2000 (10)
2026 (9)
2004 (8)
2002 (5)
1997 (1)

Lab affiliation

Max Perutz Labs, Vienna, Austria (4)
Department of Chemical and Systems Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa (2)
Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University (2)
1. Africa Health Research Institute, Durban, South Africa 2. 3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA 3. Center for AIDS Research and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA (1)
Analyitical Biochemistry and Proteomics Unit Instituto de Investigaciones Biologicas Clemente Estable/ Institut Pasteur de Montevideo (1)
Analytical Biochemistry and Proteomics Unit. Institut Pasteur de Montevideo and Instituto de Investigaciones Biológicas Clemente Estable (1)
Assistant Professor Ramalingaswami Fellow Translational Health Science and Technology Institute NCR Biotech Science Cluster 3rd Milestone, Faridabad - Gurgaon Expressway PO box # 04 FARIDABAD 121001, India (1)
CNRS (1)
CRND (1)
Case Western Reserve University (1)
Center for Tuberculosis Control of Guangdong Province (1)
Colorado State University (1)
Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, University of Cape Town, South Africa (1)
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa (1)
Department of Biological Sciences Department of Chemistry & Biochemistry University of Delaware Newark DE, 19716 (1)
Department of Biological Sciences, Department of Chemistry & Biochemistry University of Delaware Newark DE, 19716 (1)
Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa. (1)
Department of Biomedical Sciences, Stellenbosch University, South Africa (1)
Department of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, USA (1)
Department of Glycobiology, Institute of Chemistry, Slovak Academy of Sciences (1)
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 9HN (1)
Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa, 7925 (1)
Department of Microbiology University of Massachusetts Amherst USA (1)
Department of Microbiology and Immunology, UNC-Chapel Hill (1)
Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia (1)
Department of Microbiology, Monash University, Australia (1)
Department:Intergrated biomedical sciences,Division:Chemical biology,Institute of infectious diseases and Molecular medicine(IDM),Faculty of health science, University of Cape Town, South Africa (1)
Division of Chemical and Systems Biology, Department of Integrative Biomedical Science, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa. (1)
Division of Computational and Systems Biology, Department of Integrative Biomedical Science, Faculty of Health Science, University of Cape Town, South Africa. (1)
Freie Universität Berlin Institut für Biologie-Mikrobiologie Königin-Luise-Straße 12-16 14195 Berlin Germany (1)

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PatA mediates biofilm formation and drugs resistance through regulating the synthesis of glycolipids and lipids in mycobacterium PatA mediates a novel mycolic acid synthesis pathway and regulates biofilm formation in mycobacterium

Glycolipids and lipids are prominent components of bacterial cell wall that play critical roles not only in maintaining the biofilm formation but also in resistance to environmental stress. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of phosphatidyl-myo-inos...

2023-05-22 | MTBLS6758 | MetaboLights

Proteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin

Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.

ORGANISM(S): Mycobacterium Smegmatis Str. Mc2 155 (ncbitaxon:246196)

2019-03-18 | MSV000083589 | MassIVE

Generation and characterization of thiol-deficient Mycobacterium tuberculosis mutants

Mycothiol (MSH) and ergothioneine (ERG) are thiols able to compensate for each other to protect mycobacteria such as Mycobacterium smegmatis against oxidative stress. Gamma-glutamylcysteine (GGC), another thiol and an intermediate in ERG biosynthesis has detoxification abilities. Five enzymes are in...

2018-07-05 | MTBLS661 | MetaboLights

Differentially regulated genes induced in Mycobacterium smegmatis by in vitro acid-nitrosative multi-stress

Transcriptional profile of Mycobacterium smegmatis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MSMEG-K vs. MSMEG-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, independently grown and h...

ORGANISM(S): Mycobacterium smegmatis str. MC2 155

2013-11-05 | E-GEOD-34622 | biostudies-arrayexpress

Transcription profiling by array of the complete GlnR nitrogen-response regulon in Mycobacterium smegmatis

BACKGROUND: Nitrogen is an essential element for bacterial growth and an important component of biological macromolecules. Consequently, responding to nitrogen limitation is critical for bacterial survival and involves the interplay of signalling pathways and transcriptional regulation of nitrogen a...

ORGANISM(S): Mycobacterium smegmatis

2013-04-24 | E-BUGS-143 | biostudies-arrayexpress

Mycobacterium smegmatis: CarD depletion (mgm1703) vs Control (mgm1701)

Transcriptional profiling of Mycobacterium smegmatis comparing the effects of wild type levels of CarD expression with CarD depletion. Transcriptional profile of the mgm1701 control strain was compared with that of mgm1703, a strain where CarD transcription is regulated by a Tet-On system. Both stra...

ORGANISM(S): Mycobacterium smegmatis

2010-05-16 | E-GEOD-15437 | biostudies-arrayexpress

Transcription profiling by array of Mycobacterium smegmatis response to nitrogen stress using bipartite active modules

BACKGROUND: The ability to adapt to environments with fluctuating nutrient availability is vital for bacterial survival. Although essential for growth, few nitrogen metabolism genes have been identified or fully characterised in mycobacteria and nitrogen stress survival mechanisms are unknown. RESUL...

ORGANISM(S): Mycobacterium smegmatis

2013-06-10 | E-BUGS-140 | biostudies-arrayexpress

Expression analysis of Mycobacterium smegmatis delta-MSMEG_0166 mutant

Investigation of whole genome gene expression level changes in a Mycobacterium smegmatis mc2 155 delta-MSMEG_0166 mutant, compared to the wild-type strain. MSMEG_0166 is a transcriptional regulator in the gntR family. Mutations in MSMEG_0166 result in hypersensitivity to the bactericidal ubiquitin p...

ORGANISM(S): Mycobacterium smegmatis str. MC2 155

2011-01-06 | E-GEOD-26474 | biostudies-arrayexpress

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Carbon metabolism in Mycobacterium smegmatis was analysed using reverse-phase chromatography coupled to orbitrap high-resolution mass spectrometer using trypsin digestion. MS/MS files were searched against the Mycobacterium smegmatis strain MC2-155 database Release 1 - July 2010 ) by MaxQuant softwa...

ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

2014-07-09 | PXD000253 | Pride

Mycobacterium smegmatis: I-SceI homing endonuclease generated genomic DNA damage in Darr strains expressing ArrWT, ArrH18A, ArrD83A, or an empty vector vs WT M. smegmatis Mc2155 (mgm182, site(+))

Transcriptional profiling of Mycobacterium smegmatis comparing strains undergoing I-SceI generated DNA damage at a single genomic locus Gene designations are the updated annotation Four comparisons were made, all with log phase cultures and no ATc added. Darr Site(+) with an empty vector compared to...

ORGANISM(S): Mycobacterium smegmatis

2011-07-14 | E-GEOD-30635 | biostudies-arrayexpress

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