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MetabolomicsMulti-0mics and Machine Learning-Based Profiling of Severity signatures in Mycoplasma Pneumoniae Infection in children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children. Yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-04 | MTBLS13511 | MetaboLights
MetabolomicsValidation: Multi-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-05 | MTBLS13504 | MetaboLights
MetabolomicsMulti-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection

Respiratory viral co-infections in children with Mycoplasma pneumoniae pneumonia (MPP) are common and cause severe clinical manifestations. However, the exact pathogenic mechanisms of MPP co-infections are still unclear. In this study, we conducted a large-scale clinical analysis of 3,106 MPP pat...

2025-11-25 | MTBLS12635 | MetaboLights
ProteomicsMycoplasma pneumoniae processes functionally diverse proteins (N-Terminiome & Surfaceome)
Mycoplasma pneumoniae is a significant cause of pneumonia, particularly in children, the elderly and the immunocompromised, and post infection sequelae affecting organ sites distant to the respiratory tract are common. It is also a model pathogen where extensive ‘omics’ studies have been conducted t...
ORGANISM(S): Mycoplasma pneumoniae Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2021-05-01 | PXD022356 | Pride
Pneumonia Affinity N-terminiome Mycoplasma Surfaceome 
TranscriptomicsPhenome analysis of Mycoplasma pneumoniae
To discover new gene functions in Mycoplasma pneumoniae, cells were treated with different drugs/perturbations.
ORGANISM(S): Mycoplasma pneumoniae M129 
2016-04-01 | E-MTAB-3771 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Mycoplasma pneumoniae II
To reconstruct the gene regulatory network of Mycoplasma pneumoniae, cells were treated with different drugs/perturbations or were challenged by gain or loss of function of candidate regulators, or a combination of both.
ORGANISM(S): Mycoplasma pneumoniae M129 
2016-04-01 | E-MTAB-3773 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Mycoplasma pneumoniae I
To reconstruct the gene regulatory network of Mycoplasma pneumoniae, cells were treated with different drugs/perturbations or were challenged by gain or loss of function of candidate regulators, or a combination of both.
ORGANISM(S): Mycoplasma pneumoniae M129 
2016-04-01 | E-MTAB-3772 | biostudies-arrayexpress
ProteomicsLipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease
Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date, VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination with M. pneumoniae lipid...
ORGANISM(S): Mycoplasma pneumoniae 19294 
2020-04-09 | PXD016814 | Pride
Lipid associated membrane proteins Q exactive hf Mycoplasma pneumoniae 
ProteomicsLabel-free shotgun proteomics of Mycoplasma pneumoniae grown in serum-free medium
We developed a serum and animal component-free medium capable of supporting robust growth of the genome-reduced bacterium Mycoplasma pneumoniae. Here, we analyzed the proteome of the wild-type strain grown in serum-free vB13 medium compared to rich medium (Hayflick medium).
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) Bacteria 
2023-04-05 | PXD037431 | Pride
Mycoplasma pneumoniae Serum-free medium 
ProteomicsQuantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants
Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia in children and adolescents. Because of the wide application of macrolides in clinical treatment, macrolide-resistant M. pneumoniae strains have become increasingly common worldwide. However, the molecular mechanisms ...
ORGANISM(S): Mycoplasma pneumoniae 
2021-02-25 | PXD022220 | Pride
Drug resistance Mycoplasma pneumoniae Quantitative proteomic technique Differentially expressed proteins Whole proteomes 
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