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TranscriptomicsGene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-04-03 | E-GEOD-39119 | biostudies-arrayexpress
MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsComprehensive atlas of the myelin basic protein interaction landscape
Intrinsically disorder myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively charged and lacks distinct structure in solution and therefore its intracellular part-ners are still mostly enigmatic. Here w...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028685 | Pride
Protein-protein interaction Liquid chromatography-tandem mass spectrometry Myelin basic protein Formaldehyde-induced cross-linking 
TranscriptomicsGene expression profiling of CD4+myelin basic protein specific T cells
CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. However how these T cells become able to transgress the blood brain barrier is not CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. Here a gene expression profile of the pathogenic T ...
ORGANISM(S): Rattus norvegicus 
2012-08-23 | E-GEOD-38645 | biostudies-arrayexpress
GenomicsMyelin basic protein is an RNA chaperone in microglial nuclear retro-transport
Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport
PRJNA1465723 | ENA
TranscriptomicsImmunodominant myelin basic protein fragments induce mechanical hypersensitivity.
An insulating myelin sheath ensures saltatory conduction of mechanosensory A afferents. Myelin damage results in the electrical instability of A fibers and the ability to generate pain in response to light touch/pressure (mechanical allodynia). We have hypothesized and then established that the re...
ORGANISM(S): Rattus norvegicus 
2012-03-03 | E-GEOD-34868 | biostudies-arrayexpress
ProteomicsProteome profile of myelin in the zebrafish brain
While the myelin proteome is well characterized in mice, much less is known about the protein composition of myelin in non-mammalian species such as zebrafish (Danio rerio), despite its increasing popularity as model organism for myelin biology. Here, we assess the proteome of myelin biochemically p...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-03-22 | PXD023037 | Pride
Transcriptome Oligodendrocyte Mbp Label-free proteomics Teleost Cd59 Central nervous system (cns) Mpz Danio rerio Plp Zebrafish Myelin proteome 
ProteomicsThe CNS myelin proteome: Deep profile and persistence after post-mortem delay
We revisited the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. A data-independent acquisition (DIA) workflow with alternating low and elevated energy (MSE) provided the h...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-16 | PXD020007 | Pride
Mass spectrometry Oligodendrocyte Proteolipid protein (plp) Central nervous system (cns) Label-free proteomics Myelin basic protein (mbp) Post mortem-delay Cyclic nucleotide phosphodiesterase (cnp) Myelin proteome Transcriptome Demyelination Autopsy 
TranscriptomicsExon Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-06-30 | E-GEOD-39120 | biostudies-arrayexpress
ProteomicsWhite matter integrity requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. Using 3D electron microscopy, mass spectrometry imaging, and quantitative proteome analysis, we addressed the question how myelin function is affected by myelin turnover. We studie...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-14 | PXD025180 | Pride
Shiverer Myelin basic protein (mbp) Myelinoid body Juxtaparanode Myelin turnover Whole optic nerve proteome Optic nerve Fib-sem 3d reconstruction Nanosims 
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