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TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress
ProteomicsMyelin proteome alterations upon oligodendroglial deletion of CDC42 and its effector proteins CDC42EP1/CDC42EP2
The regular structure of healthy CNS myelin sheaths requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. Their assembly scaffolds the innermost non-compacted myelin layer as a late step of CNS myelin maturation and their di...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-30 | PXD066943 | Pride
Label-free protein quantification White matter Cytoskeleton Oligodendrocyte Septins Mass spectrometry Myelination Myelin pathology Myelin proteome 
TranscriptomicsIdentification of Myelin-gene Regulatory Factor as a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named Myelin-gene Regulatory Factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodend...
ORGANISM(S): Mus musculus 
2009-05-31 | E-GEOD-15303 | biostudies-arrayexpress
ProteomicsDevelopmental maturation but no sex-dependent divergence of the murine CNS myelin proteome
To assess whether the CNS myelin proteome varies within the same species, we used quantitative mass spectrometry to compare myelin purified from mouse brains at three developmental timepoints (P18, P75, 6 months), brains of male and female mice, and four CNS regions (cortex, corpus callosum, optic n...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD053062 | Pride
Axon/glia-interaction Label-free protein quantification White matter Mass spectrometry Myelin maturation Oligodendrocyte Central nervous system (cns) Myelin proteome 
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
GenomicsHuman Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling
Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling
PRJNA1268443 | ENA
GenomicsThe X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
The X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
PRJNA991995 | ENA
ProteomicsThe X-Linked Intellectual Disability gene, ZDHHC9, is important for oligodendrocyte maturation and myelin formation
Two percent of all patients with X-linked intellectual disability (XLID) exhibit loss-of-function mutations in the palmitoylating enzyme, ZDHHC91,2. One of the main anatomical deficits observed in these patients is a decrease in corpus callosum volume and a disruption of white matter integrity. We d...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-30 | MSV000092318 | MassIVE
UnknownAnalysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin.
Not available
S-EPMC3931731 | biostudies-literature
UnknownDevelopmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome.
Not available
S-EPMC11660532 | biostudies-literature
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