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TranscriptomicsGenome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.
This SuperSeries is composed of the following subset Series: GSE41130: Expression profiling of Low-Risk Myelodysplastic Syndromes (MDSs) GSE41215: Methylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41216 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs)
Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However,...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41215 | biostudies-arrayexpress
TranscriptomicsExpression data of Low-Risk Myelodysplastic Syndromes (MDSs)
Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However,...
ORGANISM(S): Homo sapiens 
2012-09-25 | E-GEOD-41130 | biostudies-arrayexpress
ProteomicsOxidative stress in myelodysplastic syndromes
Control of oxidative stress in the bone marrow (BM) is key for maintaining the balance between self-renewal, proliferation, and differentiation of hematopoietic cells. Breakdown of this regulation can lead to diseases characterized by BM failure such as the myelodysplastic syndromes (MDS). To better...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD013609 | Pride
Carbonylation Deferasirox Oxidative stress Myelodysplastic syndromes 
TranscriptomicsMyelodysplastic Syndromes (MDS) and Acute Myeloid Leukaemia (AML)
A 10K cDNA microarray was used to compare neutrophil RNA from 21 MDS patient and 2 AML patients to pooled neutrophil RNA from 7 healthy controls.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-GEOD-971 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for 5q- myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are uncommon entities, heterogeneous clinically and cytogenetically. Recently, a new drug, Lenalidomide, has demonstrated to be very effective in patients with MDS and 5q- reaching 70% of hematological responses whereas patients with MDS without 5q- has only 20-30% of...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-59244 | biostudies-arrayexpress
TranscriptomicsMyelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
Gene expression analysis of purified hematopoietic stem and progenitor cells isolated from low to intermediate risk MDS patients and age-matched normal healthy controls. Analysis of lineage associated genes and PCA clustering of populations
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-55689 | biostudies-arrayexpress
TranscriptomicsComprehensive array CGH of normal karyotype Myelodysplastic syndrome reveals hidden recurrent and individual genomic copy number aberrations with prognostic relevance
About 40% of patients with myelodysplastic syndromes (MDS) present with a normal karyotype and they are facing different courses of disease. To advance the biological understanding and find molecular prognostic markers we performed a high resolution oligonucleotide array study of 107 MDS patients (F...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-24602 | biostudies-arrayexpress
ProteomicsMacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes
Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually affecting also the mesenchymal stromal cells (MSCs) compartment. Stromal cells are indeed epigenetically reprogramme...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039866 | Pride
Myelodysplastic syndromes Proteomics Macroh2a1.1 
TranscriptomicsTranscription profiling of CD34+ cells from the bone marrow of Myelodysplastic syndrome patients and healthy controls
In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregu...
ORGANISM(S): Homo sapiens 
2010-03-24 | E-GEOD-19429 | biostudies-arrayexpress
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