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MetabolomicsThe effect of the MYH9 in endothelial cells on metabolism

This document focuses on exploring the specific impact of MYH9 on the metabolic processes of vascular endothelial cells. To achieve this, a well-designed experimental approach was adopted: human umbilical vein endothelial cells (HUVECs) were subjected to different treatments using adenoviruses, i...

2026-03-05 | MTBLS12819 | MetaboLights
TranscriptomicsSix homeoproteins and a linc-RNA cooperate at the fast MYH locus to lock terminal fast myofibre phenotype
Thousands of long intergenic noncoding RNAs (lincRNAs) are encoded by the mammalian genome, which were reported to have multiple biological functions as transcriptional activators acting in cis 1 or trans 2, transcriptional repressors 3,4 or miRNAs decoys 5,6. However, the function of most lincRNAs ...
ORGANISM(S): Mus musculus 
2014-04-27 | E-GEOD-46151 | biostudies-arrayexpress
TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsBAC CGH array profiling using Phi29-amplified colon mucosa of microdissected samples from APC and MYH mutation carriers.
Details of the series are available in the publication Cardoso J. et al., “Chromosomal instability in MYH- and APC-mutant adenomatous polyps”, Cancer Research, accepted for publication. Abstract of the publication: “The vast majority of colorectal cancers display genetic instability, either in...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-3898 | biostudies-arrayexpress
ProteomicsIdentification of BER/SSBR proteins and the DNA glycosylases MPG, UNG2, MYH, NTH1, NEIL1 and NEIL3 in replisomes Batch 3
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD004324 | Pride
Ber Batch 3 Ipond Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 1
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004288 | Pride
Ber Ipond Batch 1 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsMonitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication, Batch 2
Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision repair (BER) is the main pathway for repair of base lesions, but how BER is...
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD004494 | Pride
Ber Ipond Batch 2 Orbitrap Ssbr Replication Quantification Replisome Label free 
ProteomicsEnlightening the decay: a combined experimental and computational analysis of mantATP turnover in skinned muscle fibers
Myosin is the primary motor protein in skeletal muscle, responsible for ATP hydrolysis that drives muscle contraction. In addition to force production, myosin consumes ATP during rest in futile cycles, a phenomenon associated with the Super Relaxed State (SRX), distinct from the disordered Relaxed S...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD060451 | Pride
Myh extraction Ghost fiber Single cell Muscle 
TranscriptomicsAnalysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We developed 3' region extraction and deep sequencing (3'READS) to address mispriming issues that commonly plague poly(A) site (pA) identification, and we used the method to comprehensively map pAs in the mouse genome. T...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-42398 | biostudies-arrayexpress
TranscriptomicsNuclear scaffold and matrix attachment of HeLa chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-13774 | biostudies-arrayexpress
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