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TranscriptomicsmRNA sequencing of two brain regions (prefrontal cortex and hippocampus) and left myocardial tissue in mice with chronic heart failure vs. sham-operated control mice
After induction of ischemic chronic heart failure (CHF), mice exhibited depression-like behavior, in terms of increased anhedonia, and decreased both exploratory activity and interest in novelty. On histology, ischemic CHF mice showed no alterations in overall cerebral morphology. To further evaluat...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-55280 | biostudies-arrayexpress
TranscriptomicsPolymicrobial sepsis-induced Myocardial Depression Transcriptional Profile
To describe the transcriptional changes associated with polymicrobial-sepsis induced myocardial depression in wild type and iNOS deficient mice. Keywords: myocardium, contractility, differential gene expression, nitric oxide synthase, infection We compared the transcriptional profile of C57/BL6 WT m...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-9667 | biostudies-arrayexpress
ProteomicsQuantitative analysis of the global proteome of heart tissue in septic shock
Nowadays, sepsis and septic shock have become major public health problems, which are the main cause of death among patients admitted to the intensive care units. Notably, myocardial dysfunction during sepsis, usually called sepsis-induced myocardial depression, is common in septic shock patients wh...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-19 | PXD029649 | Pride
Shock Sepsis Proteome Myocardial depression 
ProteomicsShuangxinfang in Rats with Depression-behavior post Acute Myocardial Infarction from Proteomics
AMI models were established and PCF was administered in rats. Subjects were then assessed in an open field test recapitulating symptoms of depression. Afterward, pharmacoproteomic profiling of the hippocampus and peri-infarct border zone (BZ) was performed using a label-free liquid chromatography-ta...
ORGANISM(S): Rattus Norvegicus 
PXD027832 |
TranscriptomicsPolymicrobial sepsis-induced Myocardial Depression Transcriptional Profile
To describe the transcriptional changes associated with polymicrobial-sepsis induced myocardial depression in wild type and iNOS deficient mice. Keywords: myocardium, contractility, differential gene expression, nitric oxide synthase, infection
ORGANISM(S): Mus musculus 
2010-11-17 | GSE9667 | GEO
MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
ProteomicsDysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients
A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-07 | MSV000086425 | MassIVE
GenomicsMus musculus
Polymicrobial sepsis-induced Myocardial Depression Transcriptional Profile
PRJNA103547 | ENA
TranscriptomicsTranscription profiling of blood from two human donors was incubated for timepoints up to 24 hours in the presence and absence of live meningococci
Blood from two donors was incubated for timepoints up to 24 hours in the presence and absence of live meningococci. The donors are labelled NP and SW. 'SWB' refers to blood that was incubated with meningococci; 'Unstim' refers to control blood incubated in the absence of meningococci. Duplicate arr...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2328 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of whole blood incubated with live meningococci
Blood from two donors was incubated for timepoints up to 24 hours in the presence and absence of live meningococci. The donors are labelled NP and SW. 'SWB' refers to blood that was incubated with meningococci; 'Unstim' refers to control blood incubated in the absence of meningococci. Duplicate arr...
ORGANISM(S): Homo sapiens 
2005-12-29 | E-GEOD-3934 | biostudies-arrayexpress
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