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Skeletal muscle is a complex syncytial arrangement of an array of cell types and, in the case of muscle specific cells (myofibers), sub-types. There exists extensive heterogeneity in skeletal muscle functional behaviour and molecular landscape, at the cell composition, myofiber sub-type and intra-my...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD061287 | Pride
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
Skeletal muscle is primarily composed of myofibers responsible for contraction. In muscular diseases, these fibers undergo structural and functional changes, often marked by increased regeneration, atrophy and fibrosis. These features are also found in Inclusion Body Myositis (IBM)—a progressive myo...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069042 | Pride
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
Caloric restriction rejuvenates myofiber growth in heart failure
Loss of G9a in myofiber accelerates muscle regeneration
Single myofiber RNA-seq of young and old mice
Heart failure with preserved ejection fraction (HFpEF) is characterised by a distinct but poorly understood in skeletal muscle pathology. In a rat model ZSF1, we identify impaired myonuclear accretion as a mechanism for ablated myofiber growth in HFpEF following resistance exercise intervention. Mus...
ORGANISM(S): Rattus norvegicus 
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