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TranscriptomicsEffect of prolonged stretch on transcript profile of human pregnant myometrium
Context: Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism is unknown. Objectives: To identify a targetable mechanism mediating the effect of stretch on human myometrium. Design: Myometrial explants, prepared from biopsies obtained at elective caesarean de...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-31329 | biostudies-arrayexpress
TranscriptomicsEffect of Medroxyprogesterone Acetate on Transcript Profile of Human Pregnant Myometrium
Context: Progesterone is important physiologically and therapeutically to maintain uterine quiescence during pregnancy. It acts in part through controlling myometrial gene expression. Objective: To use expression microarray and qRT-PCR validation to determine the changes in gene expression induced ...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-22961 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of uterin leiomyoma and myometrium with or without leiomyoma [Methylation data]
Profiles of genome-wide DNA methylation were investigated in leiomyomas and in myometrium with and without leiomyomas. Profiles of DNA methylation in the myometrium with and without leiomyomas were quite similar while those in leiomyomas were distinct. Bisulphite converted DNA from the three uterin...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-45187 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat uterine myometrium -effect of estrogen
Uterine tissue is highly responsive to estrogen, which plays a mayor role in sympathetic innervation remodeling in myometrium; Microarrays were used to investigate which estrogen resposive myometrial proteins can be involved in innervation modulation Experiment Overall Design: Mature female rats wer...
ORGANISM(S): Rattus norvegicus 
2008-06-17 | E-GEOD-9117 | biostudies-arrayexpress
Proteomicsproteome of human myometrium landscape in labor and non-labor
Proteome data from 20 myometrium (in labor, IL, n = 10; non-labor, NL, n = 10) was performed by quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS).
ORGANISM(S): Homo sapiens (Human) 
2021-09-24 | PXD027906 | Pride
Proteome Myometrium Labor 
TranscriptomicsTranscription profiling of rat myometrium in the transition from late pregnancy to parturition
The process of parturition involves the complex interplay of factors that changes the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery using high-density DNA mi...
ORGANISM(S): Rattus norvegicus 
2008-10-25 | E-GEOD-12799 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of uterin leiomyoma and myometrium with or without leiomyoma [Expression data]
Profiles of genome-wide DNA methylation were investigated in leiomyomas and in myometrium with and without leiomyomas. Profiles of DNA methylation in the myometrium with and without leiomyomas were quite similar while those in leiomyomas were distinct. Total RNA from the three uterine leiomyoma, th...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-45188 | biostudies-arrayexpress
TranscriptomicsMeDIP assay using human myometrium of women with preterm labor of different phenotypes vs. normal term labor
Preterm birth is multifactorial in origin with several distinct clinical phenotypes of differing etiologies, including idiopathic preterm birth. Preterm birth involves the interaction of genetic, societal and environmental factors such as nutrition, lifestyle and stress that may modulate the length ...
ORGANISM(S): Homo sapiens 
2017-05-04 | E-GEOD-71123 | biostudies-arrayexpress
TranscriptomicsProfiling uterine fibroid specimens with an in-house array representing all 90 human tyrosine kinases and their ligands
The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. For this, total RNA samples extracted from 42 pairs of matched fibroid and adjacent myometrial tissues were hybridized to a set of 840 customi...
ORGANISM(S): Homo sapiens 
2009-11-20 | E-GEOD-19127 | biostudies-arrayexpress
GenomicsmiRNA of human myometrium in labor
miRNA of human myometrium in labor
PRJNA778741 | ENA
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