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ProteomicsSerum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially d...
ORGANISM(S): Bos taurus (Bovine) 
2023-05-10 | PXD038475 | Pride
Myxomatous mitral valve disease Degenerative mitral valve disease Tmt proteomics Dogs Serum 
ProteomicsADAMTS7, a target in atherosclerosis, cooperates with homolog ADAMTS12 to protect against myxomatous valve degeneration
The metalloprotease ADAMTS7, a drug target in atherosclerosis and vascular restenosis, is thought to have no relevant physiological role in the cardiovascular system. However, potential cooperation with its close homolog, ADAMTS12, that may mask such a role remains unexplored. The objective of the p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-07 | PXD055550 | Pride
Metalloproteinase Hypertrophy Chondroitin sulfate Heart valve Fibrosis Adamts Regurgitation Extracellular matrix Myxomatous valve 
GenomicsMyxomatous Mitral Valve Degeneration Associated with Elastin Accumulation in LTBP2-Deficient Mice
Myxomatous Mitral Valve Degeneration Associated with Elastin Accumulation in LTBP2-Deficient Mice
PRJNA1514404 | ENA
UnknownMacrophage Transitions in Heart Valve Development and Myxomatous Valve Disease.
Not available
S-EPMC5823761 | biostudies-literature
TranscriptomicsCirculating microRNA profiling by array in dogs with myxomatous mitral valve degeneration (MMVD) and pulmonic stenosis (PS) compared with healthy dogs
In this study, we aimed to demonstrate expression profiles of circulating microRNAs (miRNAs) in dogs with eccentric or concentric cardiac hypertrophy, and investigate whether there is a difference in miRNA expression according to the type of cardiac hypertrophy. Dogs with myxomatous mitral valve deg...
ORGANISM(S): Canis lupus familiaris 
2021-03-24 | E-MTAB-10029 | biostudies-arrayexpress
GenomicsMitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease
Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease
PRJNA900263 | ENA
UnknownDevelopmental basis for filamin-A-associated myxomatous mitral valve disease.
Not available
S-EPMC3444235 | biostudies-literature
GenomicsMitral valve interstitial Tissue: Myxomatous P2 prolapse of the mitral valve vs. Control
Mitral valve interstitial Tissue: Myxomatous P2 prolapse of the mitral valve vs. Control
PRJNA431911 | ENA
UnknownMyxomatous mitral valve disease bench to bedside: LDL-density-pressure regulates Lrp5.
Not available
S-EPMC4048944 | biostudies-literature
TranscriptomicsTranscription profiling of mouse deficient for Fibrillin-1
Different fibrillin-1 mutant mice
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1852 | biostudies-arrayexpress
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