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ProteomicsIdentification of N-terminal SUMOylation of mouse cofilin-1 by IP-MS
Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. As a key regulator of actin cytoskeleton dynamics, cofilins (...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038392 | Pride
Mouse Cofilin-1 Ip-ms N-terminal sumoylation 
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
ProteomicsYeast ORC sumoylation status fine-tunes origin activity
Sumoylation is emerging as a post-translation modification important for chromosome duplication and stability. The origin recognition complex (ORC), which directs DNA replication initiation by loading the MCM replicative helicases onto origins, is sumoylated in both yeast and human cells. However, t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD032977 | Pride
Orc2 Sumo Yeast 
UnknownN-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization.
Not available
S-EPMC10502023 | biostudies-literature
UnknownN-terminal α-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis.
Not available
S-EPMC12748583 | biostudies-literature
ProteomicsSUMOylation proteomic analysis in mouse liver
Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 hours of CCl₄-induced liver injury in mice. K...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD065419 | Pride
Senp3 Protein sumoylation Liver 
ProteomicsSimulated microgravity-induced changes in SUMOylation and protein expression in Saccharomyces cerevisiae
This study investigated the impact of simulated microgravity (SMG) on SUMOylation and protein expression in Saccharomyces cerevisiae. Utilizing a rotating wall vessel to simulate microgravity conditions, the research employed SILAC labeling and bottom-up proteomics to differentiate gravity vs SMG fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-01-19 | PXD070877 | Pride
Rotating wall vessels Silac Simulated microgravity Proteomics Saccharomyces cerevisiae 
ProteomicsA ZNF-nanobody fusion reveals SUMOylation-dependent changes in protein localization
SUMOylation is a post-translational modification regulating protein localization, stability, and activity, with effects varying depending on the identity of the conjugated SUMO protein (SUMO1 or SUMO2/3) and type of SUMOylation (mono-, multi-, or poly-). We previously developed a small 32 amino acid...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD069854 | Pride
UnknownInflammatory mediators increase SUMOylation of retinoid X receptor α in a c-Jun N-terminal kinase-dependent manner in human hepatocellular carcinoma cells.
Not available
S-EPMC3716323 | biostudies-literature
TranscriptomicsEliminating SF-1 (Nr5a1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development.
Sumoylation is generally considered a repressive mark for many transcription factors. However, the in vivo importance of sumoylation for any given substrate remains unclear and is questionable because the extent of sumoylation appears exceedingly low for most substrates. Here, we permanently elimina...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-30078 | biostudies-arrayexpress
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