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TranscriptomicsTranscription profiling of S. cerevisiae reveaks increasing nadh oxidation reduces overflow metabolism
When the yeast Saccharomyces cerevisiae is subjected to increasing glycolytic fluxes under aerobic conditions, there is a threshold value of the glucose uptake rate at which the metabolism shifts from being purely respiratory to mixed respiratory and fermentative. This shift is characterized by etha...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-14 | E-GEOD-6277 | biostudies-arrayexpress
TranscriptomicsSteroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis
SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycoly...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-GEOD-56843 | biostudies-arrayexpress
ProteomicsCharacterization of ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I)
This project contains MALDI-TOF/TOF spectra derived from the ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I).
ORGANISM(S): Bos Taurus 
2022-07-29 | PXD031179 | JPOST Repository
ProteomicsThe metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiency
We investigated the essentiality of the three NADH dehydrogenases of the respiratory chain of the obligate aerobe Pseudomonas taiwanensis VLB120 and the impact of the knockouts of corresponding genes on its physiology and metabolism.
ORGANISM(S): Pseudomonas taiwanensis 
2020-04-08 | PXD013623 | Pride
Pseudomonas  nadh dehydrogenase  respiratory activity  oxidative stress  electron transport chain 
ProteomicsA Bacillales-specific tubular scaffold essential for NADH dehydrogenase activity
Respiratory type II NADH:quinone oxidoreductases (NDH-II) are typically monotopic flavoproteins that make direct contact with the membrane to access the quinone pool. Here, we show that in Bacillus subtilis, one NDH-II, termed Ndh, assembles with the helical membrane plugin (HMP) protein YjlC and fo...
ORGANISM(S): Escherichia coli (strain K12) 
2026-09-07 | PXD069025 | Pride
Nadh dehydrogenase   bacillales   helical membrane plugin proteins   electron transfer chains Quinone-reacting oxidoreductase 
MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
GenomicsPhysiological responses of Saccharopolyspora erythraea towards perturbation of intracellular NADH/NAD+
Physiological responses of Saccharopolyspora erythraea towards perturbation of intracellular NADH/NAD+
PRJNA602682 | ENA
GenomicsNADH Inhibition of SIRT1 Links Energy State to Transcription During Time-Restricted Feeding
NADH Inhibition of SIRT1 Links Energy State to Transcription During Time-Restricted Feeding
PRJNA635381 | ENA
ProteomicsMetabolic reprogramming of Vibrio cholerae impaired in respiratory NADH oxidation is accompanied with increased copper sensitivity
The electrogenic, sodium ion translocating NADH:quinone oxidoreductase (NQR) from Vibrio cholerae is frequent in pathogenic bacteria and a potential target for antibiotics. NQR couples the oxidation of NADH to the formation of a sodium motive force (SMF) and therefore drives important processes such...
ORGANISM(S): Vibrio cholerae O395 
2018-06-21 | PXD009379 | Pride
Nqr Comparative proteomics Lc-ms Vibrio cholerae Na+- translocating nadh:quinone oxidoreductase Sodium bioenergetics Copper tolerance 
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
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