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TranscriptomicsGene expression profiling of cidofovir treatment and resistance inHeLa, HaCaT, and PHK cells
Cidofovir is an acyclic nucleoside phosphonate with strong antiviral activity against a broad spectrum of DNA viruses. Although it has previously been shown that cidofovir exerts an antiproliferative effect on HPV positive cells by the induction of apoptosis, the exact mechanism of action remains to...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-39293 | biostudies-arrayexpress
ProteomicsIdentifying Compartment-specific Alloimmune Targets After Renal Transplantation by integrated genomics
Microarray technology has evolved as a powerful tool over the last decade, to identify biomarkers and study the mechanisms of diseases. We propose a novel application of integrated genomics by combining transcriptional levels with serological antibody profiling after kidney transplantation, with the...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10452 | biostudies-arrayexpress
TranscriptomicsLocal regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts
The biopsy samples obtained at implantation segregated in 2 distinct groups according to donor origin, with a cluster of 319 unique identified genes higher expressed in DD compared to LD kidneys, and 329 genes lower expressed (false discovery rate <5%). Using pathway analysis software a significant ...
ORGANISM(S): Homo sapiens 
2008-04-16 | E-GEOD-11166 | biostudies-arrayexpress
UnknownMutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease.
Not available
S-EPMC3807387 | biostudies-literature
UnknownAirway proteases: an emerging drug target for influenza and other respiratory virus infections.
Not available
S-EPMC7102789 | biostudies-literature
UnknownThe Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants.
Not available
S-EPMC9346079 | biostudies-literature
UnknownA coronavirus assembly inhibitor that targets the viral membrane protein.
Not available
S-EPMC11981944 | biostudies-literature
TranscriptomicsIntragraft anti-viral-specific gene expression as a distinctive transcriptional signature for polyomavirus-associated nephropathy
Polyoma virus nephropathy (PVAN) is a common cause of kidney allograft dysfunction and loss. Microscopic descriptions of PVAN are very similar to T-cell mediated rejection (TCMR) and have unclear underlying molecular mechanisms. To identify PVAN-specific gene expression, we analyzed 162 kidney biops...
ORGANISM(S): Homo sapiens 
2016-09-30 | E-GEOD-72925 | biostudies-arrayexpress
UnknownDecreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.
Not available
S-EPMC8970457 | biostudies-literature
UnknownSynthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses.
Not available
S-EPMC7180491 | biostudies-literature
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