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TranscriptomicsRNAseq of 6 medulloblastoma cell lines
Medulloblastoma is subdivided into different subgroups: WNt, SHH, Group 3 and Group 4. Since these subgroups are associated with different OS and metastasis rates it is crucial to understand them better. Six medulloblastoma cell lines, DAOY, ONS-76, D458, HD-MB03, CHLA-01-MED, CHLA-01R-MED, have bee...
ORGANISM(S): Homo sapiens 
2022-03-02 | E-MTAB-9823 | biostudies-arrayexpress
UnknownConserved LIR-specific interaction of Sigma-1 receptor and GABARAP.
Not available
S-EPMC12398221 | biostudies-literature
TranscriptomicsUV-B-induced gene expression changes in Chlamydomonas reinhardtii
We analysed global gene expression changes in Chlamydomonas reinhardtii in response to 1h UV-B, applied at the same low level that was seen to promote subsequent UV-B stress tolerance, in order to elucidate the transcriptional reprogramming that leads to UV-B acclimation. mRNA profiles generated by ...
ORGANISM(S): Chlamydomonas reinhardtii 
2015-11-11 | E-GEOD-68739 | biostudies-arrayexpress
TranscriptomicsIdentification of novel BMP target genes in glioblastoma
It has been previously described that in glioblastoma (GBM), BMPs deplete the tumorigenic potential of glioblastoma stem cells (GSCs), promoting their differentiation towards the astrocytic lineage. To gain more insight on how BMPs regulate differentiation in GSCs, we are interested in identifying n...
ORGANISM(S): Homo sapiens 
2021-05-01 | E-MTAB-9811 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptional profiles of PBMCs from HIV-infected rapid progressors and chronic progressors
A significant percentage of HIV-infected individuals experience a sharp decline in CD4+ T cell counts and progress to AIDS quickly after primary infection. Identification of biomarkers distinguishing rapid progressors (RPs) versus chronic progressors (CPs) is critical for early clinical intervention...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44216 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis by AmpliSeq Ion Torrent to study the involvement of CXXC5 in the regulation of TGFβ/BMP target genes in glioblastoma
The aim of this work was to elucidate the role of the transcription factor CXXC5 in glioblastoma and study its involvement in the regulation of TGFβ and BMP target genes in this context. To this end we used the patient derived glioblastoma stem cells U3034MG that were either transfected with siRNA t...
ORGANISM(S): Homo sapiens 
2021-05-01 | E-MTAB-9813 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.
Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect ...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-GEOD-17046 | biostudies-arrayexpress
TranscriptomicsTransforming growth factor β (TGFβ) and BMP7 regulate glioblastoma stem cells differentiation status
Glioblastoma stem cells (GSCs) fate is controlled by environmental cues, among which cytokines play a crucial role. The transforming growth factor β (TGFβ) family signaling pathways controls GSCs. On one hand, TGFβ promotes cell proliferation in GBM, it induces the expression of platelet-derived gro...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9076 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis by AmpliSeq Ion Torrent to to understand the role of LKB1 and PARD3 in Glioblastoma biology
The aim of this work was to elucidate the role of LKB1/STK11 and PARD3 in glioblastoma multiforme cells. For this we silenced the expression of these proteins using specific siRNA in two different patient-derived glioblastoma stem cells, U3031MG and U3034MG, then we analysed how the knock-down of th...
ORGANISM(S): Homo sapiens 
2019-07-31 | E-MTAB-7724 | biostudies-arrayexpress
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (RNAi)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79652 | biostudies-arrayexpress
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