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To determine the transcriptional effects of a novel plant-based compound, dehydrobrachylaenolide, on P. falciparum, parasite cultures were treated with the compound over time. Samples were taken for analysis 2, 6, and 12 hours post-invasion of human red blood cells. Control cultures were treated sim...
ORGANISM(S): Plasmodium falciparum 3D7 
The metabolic syndrome represents a cluster of well-documented risk factors for the development of type 2 diabetes and cardiovascular disease. Next to visceral obesity, dyslipidemia and insulin resistance, excessive triglyceride accumulation in the liver has been implicated to play a role in the dev...
ORGANISM(S): Mus musculus 
Miz1deltaPOZ mothers feature a lactation defect. In order to identify genes potentially regulated by Miz1 which could explain the observed phenotype and to assess the relative expression of milk protein genes and JAK-STAT pathway components, a genome-wide cDNA microarray was performed using sampl...
ORGANISM(S): Mus musculus 
to study the effect of induced expression of TBX3 within the atrium of the heart Background: Treatment of congenital or acquired disorders of the sinus node or atrioventricular node requires insight into the molecular mechanisms for the development and homeostasis of these pacemaker tissues. In the ...
ORGANISM(S): Mus musculus 
Transposon insertion site sequencing (TIS) is a powerful tool that has significantly advanced our knowledge of functional genomics. While providing valuable insights, these applications of TIS focus on (conditional) gene essentiality and neglect possibly interesting but subtle differences in the imp...
ORGANISM(S): Saccharomyces cerevisiae 
Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions, and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy related protein (Atg) 7. Const...
ORGANISM(S): Mus musculus 
Heterologous expression of the fungal pathogen Cladosporium fulvum Avr2 in Arabidopsis plants. Experiment Overall Design: Samples used for microarray analyses were replicated three times in independent experiments and each replication consisted of 10 Avr2-expressing Arabidopsis plants and 10 Col-0 p...
ORGANISM(S): Arabidopsis thaliana 
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