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ProteomicsSpatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta, but the molecular events preceding neuronal loss remain unclear. Here, we combine spatial transcriptomics, spatial proteomics, and α-synuclein (αSyn) seed amplification assays to ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD062998 | Pride
Human Brain Pd Ilbd Sn Fibers 
ProteomicsTECPR2 HSAN9 Mutation Medulla analysis Mouse
Analysis of proteome changes in medulla in mice expressing a disease-mimicking TECPR2 variant
ORGANISM(S): Mus musculus (Mouse) 
2025-10-23 | PXD065944 | Pride
Proteomics medulla tecpr2 
ProteomicsTECPR2 HSAN9 Mutation CSF analysis Mouse
Analysis of proteome changes in CSF in mice expressing a disease-mimicking TECPR2 variant
ORGANISM(S): Mus musculus (Mouse) 
2025-10-23 | PXD059057 | Pride
Tecpr2 Csf Hsan9 Mouse 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
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