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ProteomicsSpatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta, but the molecular events preceding neuronal loss remain unclear. Here, we combine spatial transcriptomics, spatial proteomics, and α-synuclein (αSyn) seed amplification assays to ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD062998 | Pride
Human Brain Pd Ilbd Sn Fibers 
TranscriptomicsDisease duration influences gene expression in neuromelanin-positive cells from Parkinson’s disease patients
We used RNAseq to analyze genome-wide gene expression in mDA neurons isolated by LCM from postmortem cases of PD. Patients samples are derived both early after diagnosis and after prolonged disease duration. Cases of ILBD and age-matched controls were also included in the analysis.
ORGANISM(S): Homo sapiens 
2021-11-08 | GSE182622 | GEO
UnknownLewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease.
Not available
S-EPMC3578379 | biostudies-literature
UnknownDopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson.
Not available
S-EPMC10272141 | biostudies-literature
UnknownThe O-Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson's Disease.
Not available
S-EPMC8353623 | biostudies-literature
UnknownTranscriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies.
Not available
S-EPMC8028609 | biostudies-literature
UnknownAltered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases.
Not available
S-EPMC10998821 | biostudies-literature
UnknownSomatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Not available
S-EPMC3383820 | biostudies-literature
TranscriptomicsEvidence for immune response, axonal dysfunction and reduced endocytosis preceding Lewy body pathology in the substantia nigra in Parkinson’s disease
Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson’s disease (PD). To identify molecular mechanisms underlying neuronal dysfunction and alpha--synuclein pathology in the premotor phase of PD, we investigated the transcriptome of post-mortem substantia nig...
ORGANISM(S): Homo sapiens 
2015-05-12 | GSE49036 | GEO
UnknownDisease Duration Influences Gene Expression in Neuromelanin-Positive Cells From Parkinson's Disease Patients.
Not available
S-EPMC8632647 | biostudies-literature
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