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ProteomicsNALCN crosslinking experiments by BS3 crosslinker
We used BS3 as the crosslinker to identify the crosslinking sites between NALCN and other interacted proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD022119 | Pride
Nalcn Crosslinking Lc-ms/ms 
ProteomicsStructural architecture and function of the human NALCN channelosome
Chemical cross-linking coupled to mass spectrometry was used to study the subunit organization of the NALCN channelosome consisting of the proteins NALCN, FAM155A, UNC79 and UNC80. Cross-linking data was generated using the reagents disuccinimidyl suberate (DSS), pimelic dihydrazide (PDH), and 4-(4,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-23 | PXD027213 | Pride
Chemical cross-linking  dss  pdh  dmtmm  ion channel  sodium leak channel  nalcn 
GenomicsThe NALCN channel regulates metastasis and non-malignant cell dissemination (scRNA-Seq)
The NALCN channel regulates metastasis and non-malignant cell dissemination (scRNA-Seq)
PRJNA863885 | ENA
ProteomicsThe sodium leak channel NALCN is regulated by the neuronal SNARE complex
Chemical cross-linking coupled to mass spectrometry was used to study the subunit organization of the complex between human NALCN, FAM155A, SNAP25 and STX1A proteins. Cross-linking data was generated using the reagents disuccinimidyl suberate (DSS), pimelic dihydrazide (PDH), and 4-(4,6-dimethoxy-1,...
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD053999 | Pride
Chemical cross-linking  dss  pdh  dmtmm  ion channel  sodium leak channel  nalcn  snare complex 
GenomicsThe NALCN channel regulates metastasis and non-malignant cell dissemination (Bulk RNA-Seq)
The NALCN channel regulates metastasis and non-malignant cell dissemination (Bulk RNA-Seq)
PRJNA863886 | ENA
TranscriptomicsThe NALCN channel regulates metastasis and non-malignant cell dissemination (scRNA-Seq)
We identify the Sodium Leak Channel Non-Selective Protein (NALCN) as a key regulator of cancer metastasis and non-malignant cell dissemination. Among 10,022 human cancers, NALCN loss-of-function mutations were enriched in gastric and colorectal cancers. Deletion of Nalcn from gastric, intestinal or ...
ORGANISM(S): Mus musculus 
2022-08-06 | GSE210132 | GEO
TranscriptomicsThe NALCN channel regulates metastasis and non-malignant cell dissemination (Bulk RNA-Seq)
We identify the Sodium Leak Channel Non-Selective Protein (NALCN) as a key regulator of cancer metastasis and non-malignant cell dissemination. Among 10,022 human cancers, NALCN loss-of-function mutations were enriched in gastric and colorectal cancers. Deletion of Nalcn from gastric, intestinal or ...
ORGANISM(S): Mus musculus 
2022-08-06 | GSE210133 | GEO
UnknownArchitecture of the human NALCN channelosome.
Not available
S-EPMC8986805 | biostudies-literature
UnknownGenetic variants in components of the NALCN-UNC80-UNC79 ion channel complex cause a broad clinical phenotype (NALCN channelopathies).
Not available
S-EPMC6671679 | biostudies-literature
UnknownNALCN/Cch1 channelosome subunits originated in early eukaryotes.
Not available
S-EPMC12412391 | biostudies-literature
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