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TranscriptomicsGene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-16008 | biostudies-arrayexpress
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsHuman rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects
Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. Objective: To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic and healthy nasal epithelial cells (...
ORGANISM(S): Homo sapiens 
2014-07-28 | E-GEOD-52074 | biostudies-arrayexpress
TranscriptomicsNasal epithelium gene expression profiling in child respiratory allergic disease
Background: In asthma, airway epithelium remodeling can already be detected during childhood, and epithelial cells are more susceptible to virus and oxidative stress. Their exact role in natural history and severity of children allergic respiratory disease remains however surprisingly unexplored. A...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19187 | biostudies-arrayexpress
TranscriptomicscDNA microarray data after influenza A virus infection in nasal epithelial cells
A comparative gene expression analysis was performed using cDNA microarray technology in passage-2 normal human nasal epithelial cells to identify the differentially expressed genes between influenza A virus infected and uninfected cells. Two samples were analyzed. RNA was extracted from normal huma...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-46567 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nasal respiratory and olfactory epithelium
The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, includin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5019 | biostudies-arrayexpress
TranscriptomicsGene expression in CF-vs-non CF human airway epithelial cell samples obtained by nasal brushing.
A small-scale whole genome microarray study of gene expression in human native nasal epithelial cells from F508del-CFTR homozygous CF patients and non-CF controls. We used the custom designed Affymetrix HsAirwaya520108F Arrays to compare gene expression in 5 CF and 5 non CF nasal epithelial cell sam...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-40445 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of Rattus norvegicus nasal epithelial cells to treatment with various doses of formaldehyde
Formaldehyde, an important industrial chemical, is used for multiple commercial purposes throughout the industrialized world. This simple, one carbon aldehyde is a natural metabolite formed in cells throughput the body. However, it is also a rodent nasal carcinogen, when inhaled by rats every day ...
ORGANISM(S): Rattus norvegicus 
2007-10-25 | E-GEOD-7002 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from nasal epithelial cells of human smokers and nonsmokers
We are investigating the methylation profiles associated with cigarette smoke exposure. We used arrays to compare the DNA methylation profiles in healthy human smokers and nonsmokers. Nasal epithelial cells were extracted from 12 volunteers (6 smokers, 6 nonsmokers), and grown until fully differenti...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28368 | biostudies-arrayexpress
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