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ProteomicsSequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's disease and related neurodegenerative diseases. Lowering αSyn is being actively investigated as a therapeutic modality. Here we systematically map the regulatory network that controls endogenous αSyn using sequ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD048283 | Pride
Crispr Alpha-synuclein Natb inhibition Parkinson's disease Human neurons 
TranscriptomicsNatB N-terminal acetyltransferase (hNAT5) inhibition
Search for genes differently expressed when we inhibit NatB N-terminal acetyltransferase. We compare gene expression after inhibiting hNAT5 expression in Hela cells with specific siRNAs expressed with adenoviruses. Keywords: gene expression comparison
ORGANISM(S): Homo sapiens 
2008-03-12 | GSE10779 | GEO
UnknownSequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.
Not available
S-EPMC10857481 | biostudies-literature
GenomicsHomo sapiens
NatB N-terminal acetyltransferase (hNAT5) inhibition
PRJNA107461 | ENA
UnknownNatB Protects Procaspase-8 from UBR4-Mediated Degradation and Is Required for Full Induction of the Extrinsic Apoptosis Pathway.
Not available
S-EPMC11376409 | biostudies-literature
UnknownYeast NatB Regulates Cell Death of Bax-Expressing Cells.
Not available
S-EPMC12730891 | biostudies-literature
UnknownSemi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Not available
S-EPMC10728591 | biostudies-literature
TranscriptomicssiRNA knockdown of NatB N-terminal acetyltransferase (hNAT5) expression in human Hela cells with specific siRNAs
Search for genes differently expressed when we inhibit NatB N-terminal acetyltransferase. We compare gene expression after inhibiting hNAT5 expression in Hela cells with specific siRNAs expressed with adenoviruses. Experiment Overall Design: We analyzed duplicate samples and we used as controls Hela...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-10779 | biostudies-arrayexpress
UnknownNatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma.
Not available
S-EPMC5522283 | biostudies-literature
ProteomicsMeant_RSK_BioID_2019
This dataset consists of 33 raw MS files and associated peak lists and result files, acquired on an Orbitrap Fusion Tribrid mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication by Antoine Meant et al. titled: RSK promote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-07 | MSV000083414 | MassIVE
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