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ProteomicsLFQ shotgun proteomic analysis of HAP1 NatC KO cells
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human proteome (protein abundance). Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034104 | Pride
Hap1 cells Natc ko Lfq Shotgun Lc-ms/ms 
ProteomicsImpact of NatC on N-terminal acetylome
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human N-terminal acetylome. Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD034992 | Pride
Lc-ms/ms Hap cells Natc Scx N-terminal enrichment 
ProteomicsUBR4 KO analysis with TMT labeling
The impact of NatC and UBR4 on the human proteome (protein abundance). Analysis of HAP1 WT siCtr, HAP1 WT siUBR4, HAP1 NAA30 KO siCtr, and HAP1 NAA30 KO siUBR4 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034410 | Pride
Hap1 ko cells Tmt Ubr4 Lc-ms/ms 
OtherN-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochem...
ORGANISM(S): Homo sapiens 
2023-09-18 | GSE221447 | GEO
UnknownN-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Not available
S-EPMC10611716 | biostudies-literature
GenomicsN-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
PRJNA914318 | ENA
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