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In this proof-of-concept study, we tested whether placebo effects can be monitored and predicted by plasma proteins. In a randomized controlled design, 90 participants were exposed to a nauseating stimulus on two separate days and were randomly allocated to placebo treatment or no treatment on the s...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020563 | Pride
Area postrema cell types that mediate nausea-associated behaviors
Nausea, the unpleasant sensation of visceral malaise, remains a mysterious process. The area postrema is implicated in some nausea responses, and contains poorly understood brain-resident sensory neurons that are anatomically privileged to detect bloodborne signals. To investigate nausea mechanisms,...
ORGANISM(S): Mus musculus 
2020-12-07 | GSE160938 | GEO
Activation of GFRAL+ Neurons Induces Hypothermia and Glucoregulatory Responses Associated with Nausea and Torpor
GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment and may mediate metformin effects by long-term GDF15-GFRAL agonism. If GFRAL+ neurons acutely regulate glucose and energy homeostasis is however underexplored. Here, we report that cell-specific activation of GFR...
ORGANISM(S): Mus musculus 
2024-03-21 | GSE255540 | GEO
RATIONALE: Learning how often patients experience nausea and vomiting after receiving anti-vomiting medicine and chemotherapy for colorectal cancer may help doctors plan better treatment and improve patients’ quality of life. PURPOSE: This clinical trial is studying delayed nausea and vomiting in pa...
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