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TranscriptomicsEffects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: a Randomized Double-blind Placebo-controlled Trial
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota manipulation by antibiotics (7-day administration of amoxicillin, vancomycin, or placebo) affects host metabolism in 57 obese, prediabetic men. Va...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-76003 | biostudies-arrayexpress
TranscriptomicsExpression data from kidney transplantations in a Fisher-Lewis rat model: placebo and 13cisRA treatment
Most kidney allograft losses are caused by chronic allograft dysfunction (CAD). The aim of the study was to correlate changes in gene expression over time during the development of chronic damage in contrast to13cisRA Treated animal that demonstrated morphologically healthy kidneys by the end of teh...
ORGANISM(S): Rattus norvegicus 
2012-01-07 | E-GEOD-17045 | biostudies-arrayexpress
ProteomicsMolecular classification of the placebo effect in nausea by mass spectrometry
In this proof-of-concept study, we tested whether placebo effects can be monitored and predicted by plasma proteins. In a randomized controlled design, 90 participants were exposed to a nauseating stimulus on two separate days and were randomly allocated to placebo treatment or no treatment on the s...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020563 | Pride
Dia-ms Plasma Nausea Placebo 
TranscriptomicsInvestigation of placental DNA methylation in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6421 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental gene expression in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6418 | biostudies-arrayexpress
TranscriptomicsWhole blood gene expression from overweight women supplemented with quercetin or placebo
Flavonoids and fish oils have anti-inflammatory and immune-modulating influences. The purpose of the study was to determine if a mixed flavonoid-fish oil supplement (Q-Mix; 1000 mg quercetin, 400 mg isoquercetin, 120 mg EGCG from green tea extract, 220 mg EPA and 180 mg DHA from fish oil, 1000 mg vi...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-74560 | biostudies-arrayexpress
TranscriptomicsRNA-seq of healthy individuals that received placebo or gentamicin prior to YF17D vaccination
RNA was extracted from whole blood of subjects collected in Tempus tubes. We assessed host response over time following YF17D vaccination in placebo and gentamicin groups.
ORGANISM(S): Homo sapiens 
2026-05-15 | E-MTAB-16858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of PBMCs from slightly obese human males given diclofenac or a placebo to study modulation of inflammation
Mildly obese males received a diclofenac or placebo intervention to study modulation of inflammation.
ORGANISM(S): Homo sapiens 
2010-02-05 | E-TABM-740 | biostudies-arrayexpress
TranscriptomicsscAT gene expression from women with PCOS following LC n-3 PUFA or placebo supplementation
Gene expresion profiles from the scAT following 6 week LC n-3 PUFA and 6 week placebo supplementation were compared Women with PCOS were supplemented with 4g n-3 PUFA (containing 1.8g EPA and DHA) daily for 6 weeks and changes in subcutaneous adipose tissue gene expression was compared with 6 week p...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-43266 | biostudies-arrayexpress
TranscriptomicsUnexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: an Experimental Crossover Study
Intravaginal HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely disappointing. We postulated that unrecognized effects of intravaginal gels on the upper female reproductive tract (FRT) might contribute to the lower...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-58090 | biostudies-arrayexpress
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