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TranscriptomicsGenomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor ...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22615 | biostudies-arrayexpress
TranscriptomicsTranscriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumours are generally benign. However, many are invasive and some of these are aggressive with high proliferation and recurrence rates. Only metastatic tumours are considered malignant and are rare (0.2%). To identify molecular events associated with the aggressive and malignant phenotypes...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22812 | biostudies-arrayexpress
TranscriptomicsTranscriptional and post-transcriptional analysis of CD4+ T cell clones deriving from HTLV-1 infected individuals
T-cell clones were obtained by limiting dilution culture of PBMC of HTLV-1 carriers. Exon expression profiling was performed using Affymetrix exon array (Affymetrix Human Exon 1.0 ST Array) according to the manufacturer's instructions. The main objectives were to assess whether transcriptional and p...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-46518 | biostudies-arrayexpress
TranscriptomicsDefective NK cells in AML patients at diagnosis are associated with blast transcriptional signatures of immune evasion
Acute myeloid leukemia (AML) is a heterogeneous group of malignancies which may be sensitive to the natural killer (NK) cell anti-tumor response. However, NK cells are frequently defective in AML. Here, we found in an exploratory cohort (n = 46) that NK-cell status at diagnosis of AML separated pati...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-34885 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse limb tendon cells during development.
We have undertaken a screen of mouse limb tendon cells in order to identify molecular pathways involved in tendon development. Mouse limb tendon cells were isolated based on Scleraxis (Scx) expression at different stages of development: E11.5, E12.5 and E14.5 Microarray comparisons were carried out ...
ORGANISM(S): Mus musculus 
2014-01-18 | E-GEOD-54207 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of RNAs translationally regulated upon BRCA1 depletion in human mammary epithelial cells
Loss of function of the tumor suppressor BRCA1 (Breast Cancer 1) protein is responsible for numerous familial and sporadic breast cancers. We previously identified PABP1 as a novel BRCA1 partner and showed that BRCA1 modulates translation through its interaction with PABP1. We showed that the global...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40730 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
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