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GenomicNational Children's Study Vanguard Study Formative Research Study (NCS)

The National Children's Study (NCS) is a multi-year prospective epidemiological study tasked with identifying a nationally representative sample of 100,000 children and following them from pregnancy through age 21 to study environmental impacts on growth, development, and health. Determinatio...

phs000662 | dbGaP
ProteomicsIdentification of differentially expressed proteins between fused and open sutures in sagittal nonsyndromic craniosynostosis during suture development by quantitative proteomic analysis
Craniosynostosis (CS) is a common birth defect due to the premature fusion of one or more cranial sutures. It manifests with abnormal skull shape and is associated with significant morbidities such as increased intracranial pressure, vision problems, and learning disabilities. Nonsyndromic craniosyn...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-20 | MSV000085130 | MassIVE
Proteomicsnascent proteome analysis of HCT116 TP53 wild type and TP53 knockout cells treated with Neocarcinostatin (NCS) for 6h
In order to investigate the potential role of TP53 in regulating translation, HCT116 wild type and TP53 knockout cells were analyzed using both RNA sequencing, Ribosome sequencing and nascent proteome analysis. The cells were treated with 0.2 µg/ml Neocarcinostatin (NCS) to induce DNA damage and act...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD029512 | Pride
Tp53 Ncs Nascent proteome Metabolic labeling Dna damage 
TranscriptomicsDNA damage response (NCS treatment) in several siRNA-manipulated cellular systems
Response to treatment with the radiomimetic drug NCS in cells knocked-down for ATM, p53, and the Rel_A subunit of NFkB; and in control un-infected cells and cells infected with siRNA against LacZ Keywords = DNA damage Keywords = ATM Keywords = p53 Keywords = RelA Keywords: other
ORGANISM(S): Homo sapiens 
2005-03-23 | GSE1676 | GEO
TranscriptomicsRNAi knock down of ATM, p53 Rel_A subunit of NFkB or LacZ in human HEK293 cells treated with the radiomimetic drug NCS
Response to treatment with the radiomimetic drug NCS in cells knocked-down for ATM, p53, and the Rel_A subunit of NFkB; and in control un-infected cells and cells infected with siRNA against LacZ
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-1676 | biostudies-arrayexpress
UnknownDifferent Effects of His-Au NCs and MES-Au NCs on the Propagation of Pseudorabies Virus.
Not available
S-EPMC6607262 | biostudies-literature
TranscriptomicsCoupling p53 binding and nucleosome occupancy measurements at p53 binding sites
We were interested to explain why p53 binds some high affinity sites in contrast to other high affinity sites that are not bound by p53. p53 binding was measured using p53 ChIP-CHIP and in parallel nucleosome occupancy was measured on these same sites Comparison between p53 binding and nucleosome oc...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-22783 | biostudies-arrayexpress
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
GenomicsHomo sapiens
National Children's Study (NCS) Vanguard Formative Research Project L0I3-RT-01-D: Ancestry Informative Markers (AIM) among NCS Participants
PRJNA219047 | ENA
GenomicsHomo sapiens
National Children's Study (NCS) Vanguard Formative Research Project L0I3-RT-01-D: Ancestry Informative Markers (AIM) among NCS Participants
PRJNA219048 | ENA
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