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ProteomicsLoss of NDR1/2 kinases impairs endomembrane trafficking and ATG9A localisation, reduces autophagy and leads to neurodegeneration
Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases implicated in neuronal development, mitochondrial health and autophagy, but how they affect mammalian brain development in vivo is not known. Usi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD035566 | Pride
Autophagy Ndr1/2 Atg9a Neurodegeneration 
UnknownLoss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
Not available
S-EPMC9711861 | biostudies-literature
UnknownNDR1/2 kinases regulate cell polarization and cell motility through Cdc42 GTPase and Pard3 signaling in mammalian cells.
Not available
S-EPMC12636402 | biostudies-literature
GenomicsGenome-wide profiling of Smad2 and Eomesa binding in zebrafish blastulas
Study of Smad2 and Eomesa genomic binding in zebrafish blastulas, their relationship to eachother and the relaptionship between genomic binding and Ndr1 and Eomesa responsive genes as identified by microarray and RNA-seq. Replicate ChIP samples with associated input for Smad2 and Eomesa - 4x ChIP sa...
ORGANISM(S): Danio rerio 
2014-10-15 | E-GEOD-51891 | biostudies-arrayexpress
TranscriptomicsExpression data roots of Arabidopsis plants inoculated with Verticillium longisporum
Identification of genes differentially expressed in roots of Arabidopsis Col-0 and ndr1-1 mutants 48 h post inoculation with the fungal pathogen Verticillium longisporum. Arabidopsis Col-0 and ndr1-1 seeds were grown in petri dishes with liquid MS medium supplemented with 0.2% sucrose. After two wee...
ORGANISM(S): Arabidopsis thaliana 
2014-11-20 | E-GEOD-62537 | biostudies-arrayexpress
UnknownFurry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
Not available
S-EPMC7062186 | biostudies-literature
TranscriptomicsPiezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae
Candida albicans metamorphoses from benign yeast to a rigid hyphae , becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here we report that the mechanosensitive ion channel Piezo1 is indispensable for re...
ORGANISM(S): Mus musculus 
2025-05-22 | GSE279850 | GEO
TranscriptomicsPiezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae
Candida albicans metamorphoses from benign yeast to a rigid hyphae , becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here we report that the mechanosensitive ion channel Piezo1 is indispensable for re...
ORGANISM(S): Mus musculus 
2025-05-21 | GSE293094 | GEO
UnknownNDR functions as a physiological YAP1 kinase in the intestinal epithelium.
Not available
S-EPMC4426889 | biostudies-literature
UnknownNDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3.
Not available
S-EPMC5376972 | biostudies-literature
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