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ProteomicsA cereblon-based (CRBN) glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
Aberrant NLRP3 inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed to mediate NLRP3 inflammasome assembly and activation by bridging adjacent NLRP3 subunits. Hence, reduction of NEK7 protein may block NLRP3 ac...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-18 | PXD057229 | Pride
Molecular glue degrader Inflammation Nek7 Nlrp3 inflammasome Crbn 
GenomicsInhibition of NLRP3 Inflammasome Activation by A20 through Modulation of NEK7
Inhibition of NLRP3 Inflammasome Activation by A20 through Modulation of NEK7
PRJNA1064917 | ENA
GenomicsEffect of NEK7 hepatocyte knock-out on gene expression in the mice livers.
Effect of NEK7 hepatocyte knock-out on gene expression in the mice livers.
PRJNA1135198 | ENA
TranscriptomicsInhibition of NLRP3 Inflammasome Activation by A20 through Modulation of NEK7
The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. The ubiquitin-editing enzyme A20 is well known to regulate inflammation and maintain homeostasis. However, the precise molecular mechanisms by which A20 modulates the NLRP3 inflamma...
ORGANISM(S): Mus musculus 
2024-07-03 | GSE253265 | GEO
ProteomicsPriming by IKKβ recruits NLRP3 to the trans-Golgi network to enable NEK7-independent inflammasome activation
The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the context of sterile inflammatory conditions. NLRP3 activity is governed by two independent signals: The first signal primes NLRP3, rendering it responsive to the second signal, which then triggers inflammasome form...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-17 | PXD035302 | Pride
Human Lc-msms Macrophages Monocytes Innate immunity Nek7 Pattern recognition Inflammasome Nlrp3 
UnknownStructural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Not available
S-EPMC6774351 | biostudies-literature
TranscriptomicsEffect of NEK7 hepatocyte knock-out on gene expression in the mice livers.
To investigate the genes and pathways affected by depletion of hepatocyte NEK7 in the mice livers.
ORGANISM(S): Mus musculus 
2025-09-24 | GSE272141 | GEO
UnknownMechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Not available
S-EPMC4632185 | biostudies-literature
UnknownNEK7 is required for G1 progression and procentriole formation.
Not available
S-EPMC5509424 | biostudies-literature
UnknownNEK7 promotes gastric cancer progression as a cell proliferation regulator.
Not available
S-EPMC8379724 | biostudies-literature
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