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MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
MetabolomicsMaternal regulation of biliary disease in neonates via gut microbial metabolites

Maternal seeding of the microbiome in neonates promotes a long-lasting biological footprint, but how it impacts disease susceptibility in early life remains unknown. We hypothesized that feeding butyrate to pregnant mice influences the newborn’s susceptibility to biliary atresia, a severe cholang...

2022-01-11 | MTBLS2171 | MetaboLights
MetabolomicsEarly postnatal metabolic profile in neonates with different birth weight status: A pilot study

INTRODUCTION: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this ...

2021-04-28 | MTBLS2376 | MetaboLights
MetabolomicsFrom Microbiota to Metabolomics: How Bifidobacterium infantis YLGB-1496 Shields Neonates from Necrotizing enterocolitis

Bifidobacterium species are recognized as essential primary colonizers of the infant gastrointestinal tract and constitute a critical component of infant formula. Nevertheless, the precise mechanisms by which Bifidobacterium confers its protective effects against gut inflammation remain insuffici...

2025-10-20 | MTBLS13018 | MetaboLights
TranscriptomicsRapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life
Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic def...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-56575 | biostudies-arrayexpress
ProteomicsPeptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage
Hypoxic-ischemic brain injury (HIBD) causes neonatal death and serious neurological disability; however, there are currently no promising therapies for it excepting cooling. Therefore, in this study, we used peptidome analysis to identify differentially expressed peptides in cerebrospinal fluid (CS...
ORGANISM(S): Homo Sapiens 
2020-03-01 | PXD017797 |
GenomicsESBL-producing isolates from neonates in Tanzania
ESBL-producing isolates from neonates in Tanzania
PRJEB20875 | ENA
ProteomicsExtracellular vesicles in Early preterm neonates and thrombin generation
The aim of the EVENT Study (Extracellular Vesicles in Early preterm Neonates and Thrombin generation) was to characterise the circulating EVs in preterm infants, using multiple EV charac- terisation techniques, during the perinatal adaptation period and compare them to healthy full-term controls.
ORGANISM(S): Homo sapiens (Human) 
2026-01-11 | PXD064962 | Pride
Human Plasma Extracellular vesicles 
ProteomicsMass spectrometry analysis reveals developmental differences between platelets derived from neonates and adults
It has been proposed that developmental differences exist between neonatal and adult platelets. Detailed insight therein is, however, still lacking. We have now compared the platelet protein expression profile of neonates and adults employing a label-free quantitative mass spectrometry approach. In ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD004578 | Pride
Platelet Neonate Proteome Mass spectrometry Cord blood 
Genomics16S V1-V9 ONT data of feces: neonates
16S V1-V9 ONT data of feces: neonates Metagenome
PRJNA1234853 | ENA
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