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TranscriptomicsMicroarray Analysis Gene Expression Profiles in Laryngeal Muscle After Recurrent Laryngeal Nerve Injury
The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. ...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-72361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of rat retina after intra-orbital nerve transection, intra-orbital nerve crush or no treatment
Array experiment: Animals were divided into a control group (naive), which did not undergo any experimental manipulation (n=20) and two experimental groups, one receiving an intra-orbital nerve transection (IONT, n=60) and the other an intra-orbital nerve crush (IONC, n=60) Sterile precautions were ...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-MEXP-1387 | biostudies-arrayexpress
TranscriptomicsGene expression signatures following nerve injury in a rat model (0h-9h)
We used microarrays to distinguish the gene expression differences among different time points after injury. We generated proximal sciatic nerve (SN) tissues (0.5cm) at 0h, 0.5h, 1h, 3h, 6h and 9h after sciatic nerve resection.
ORGANISM(S): Rattus norvegicus 
2012-12-20 | E-GEOD-33175 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse optic nerve head after optic nerve crush
Reactive gliosis is a complex process that involves profound changes in gene expression. We used microarray to indentify differentially expressed genes and to investigate the molecular mechanisms of reactive gliosis in optic nerve head in response to optic nerve crush injury. C57Bl/6 female mice wer...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-40857 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of DRG and dorsal cord after nerve injury
Genes are up and down regualted in DRG and spinal dorsal cord after peripheral nerve injury WT male adult with sciatic and femoral nerve transection 7 days, RNA was purified from ipilateral or contralateral L4-L6 DRGs or lumbar spinal dorsal cords
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-66619 | biostudies-arrayexpress
ProteomicsQuantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends
Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-19 | PXD051266 | Pride
Digital nerve injury Quantitative mass spectrometry Signal transduction Peripheral nerve injury Nerve injury pathways Extracellular matrix Proteomics 
TranscriptomicsDifferential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17117 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse optic nerve head after elevation in intraocular pressure
Reactive astrocytes are typically studied in models that cause irreversible mechanical damage to axons, neuronal cell bodies, and glia. We evaluated the response of astrocytes in the optic nerve head to a subtle injury induced by a brief, mild elevation of the intraocular pressure. Astrocytes demo...
ORGANISM(S): Mus musculus 
2013-05-17 | E-GEOD-40009 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse sciatic peripheral nerve of uninjured mouse against implantation of a silicon device or peripheral nerve injury.
Foreign body reaction is one of the most important limiting factors to the clinical translation of implantable bioelectronics. The experiment compares the process of foreign body reaction, following the implantation of a silicon device in a mouse peripheral nerve, to that of peripheral nerve injury,...
ORGANISM(S): Mus musculus 
2022-04-30 | E-MTAB-10294 | biostudies-arrayexpress
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