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TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
TranscriptomicsGene expression signatures following nerve injury in a rat model (0d-14d)
We used microarrays to distinguish the gene expression differences among different time points after injury. We generated L4-6 dorsal root ganglia (DRG) tissues and proximal sciatic nerve (SN) tissues (0.5cm) at 0d, 1d, 4d, 7d and 14d after sciatic nerve resection.
ORGANISM(S): Rattus norvegicus 
2013-01-01 | E-GEOD-30165 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of nodose or dorsal root ganglion visceral sensory neurons from mice infected with N. brasiliensis and/or subjected to environmental stress to determine molecular signatures for post-infective visceral chemosensitivity associated with irritable bowel syndrome
Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via spinal afferents. Both stress and inflammation are implicated in visceral hypersensitivity, but the underlying molecular mechanisms of visce...
ORGANISM(S): Mus musculus 
2008-01-31 | E-JJRD-1 | biostudies-arrayexpress
TranscriptomicsComparison of adult intact naive C57Bl/6 Nogo-A KO versus WT spinal cord
Nogo-A localized on myelin adaxonal membrane in the adult CNS is well known for its role as neurite outgrowth inhibitor following a lesion. Nogo-A KO mice show enhanced regenerative/compensatory fiber growth following CNS lesion. However, changes undergoing in their intact CNS have not been studied....
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-11276 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat spinal cord from DA, PVG and congenic strains following ventral root avulsion(VRA)
The current experiment is a continuation of a previous study (E-MTAB-303) where spinal cords from a F2 (DAxPVG) intercross exposed to ventral root avulsion was studied. The F2 experiment revealed specific genetic regions of interest. Now, congenic lines, i.e. DA rats containing small inserts of PVG ...
ORGANISM(S): Rattus norvegicus 
2013-05-31 | E-MTAB-920 | biostudies-arrayexpress
TranscriptomicsMicroarray (one-color) gene expression analysis of Euglena gracilis subjected to altered acceleration during parabolic flight
Euglena gracilis is a unicellular freshwater flagellate, which uses the gravitational vector for orientation in the water column in the dark. This allows the cell to reach areas in the water column for reproduction and growth. How exactly the gravitational vector is perceived, and which intracellula...
ORGANISM(S): Euglena gracilis 
2019-07-09 | E-MTAB-8064 | biostudies-arrayexpress
TranscriptomicsChanges in Gravitaxis and Gene-Expression in an Euglena gracilis Culture over Time
Supplement S1: Figure S1. (a) Effect of culture age of Euglena gracilis on gene expression, determined with gene arrays analysis. Total number of differentially expressed genes classified into groups of fold-change-ranges in Euglena gracilis cells of different culture age (5 d, 9 d, 11 d) compared t...
ORGANISM(S): Euglena gracilis 
2024-04-01 | E-MTAB-13906 | biostudies-arrayexpress
TranscriptomicsRNA profiling of the dorsal root ganglia, spinal cord, and anterior cingulate cortex in mice with CFA-induced inflammatory pain
To investigate the molecular mechanisms underlying pain and emotion - related responses in the nervous system, this experiment focused on dorsal root ganglia (DRG), spinal cord (SC), and anterior cingulate cortex (ACC) tissues. Mice were divided into sham and complete Freund's adjuvant (CFA) - induc...
ORGANISM(S): Mus musculus 
2026-08-30 | E-MTAB-15797 | biostudies-arrayexpress
TranscriptomicsMicroarray of BAC transgenic Zfhx2 p.R1907K mutant mice (4 genomic copies) versus wild-types
A novel missense mutation has been identified in a human pain-insensitive family in the gene ZFHX2. We modelled this mutation in mice by changing the orthologous amino acid and carried out pain behaviour tests in mutant BAC transgenic mice. These showed a phenotype of hyposensitivity to noxious ther...
ORGANISM(S): Mus musculus 
2018-06-11 | E-MTAB-5650 | biostudies-arrayexpress
TranscriptomicsDefining the nociceptor transcriptome
Unbiased 'omics' techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets. The neurons of the dorsal root ganglia (DRG) are an impor...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-62424 | biostudies-arrayexpress
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