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Deep sequencing of the transcriptome of P. vivax parasite populations from vivax malaria patients with scarce parasitemia from the low transmission Brazilian Amazonian endemic region we the aim of better understanding the molecular mechanisms behind this cytoadherence and rosetting phenotypes by ide...
ORGANISM(S): Homo sapiens 
Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD010277 | Pride
This dataset aimed to investigate the transcriptional pathways driving the switch from asexual to sexual stage development of Plasmodium falciparum starting from the initial transcriptional response to variation in environmental LysoPC levels. Two culture adapted P. falciparum strains: Pf2004 from W...
ORGANISM(S): Plasmodium falciparum 3D7 
Analysis of the changes in the transcriptome of circulating neutrophils and skeletal muscle from standardized resting conditions (baseline; pre-EXTRI) to 3, 48 and 96 hours after an experimental exercise trial (EXTRI; 1 hour of cycling followed by 1 hours of running) in 8 healthy, endurance-trained,...
ORGANISM(S): Homo sapiens 
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella Homo sapiens (Human) Morganella Pseudomonas sp. 
2015-02-17 | PXD000164 | Pride
A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that m...
ORGANISM(S): Homo sapiens (Human) 
2018-07-27 | PXD008448 | Pride
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