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ProteomicsMDR1 Drug Efflux Pump Promotes Acquired and Intrinsic Resistance to Protein Degraders in Cancer Cells
PROTACs (Proteolysis-Targeting Chimeras) represent a revolutionary new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical trials. Drug resistance represents a signif...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD029233 | Pride
Mdr1 Degrader Cancer Protac Drug resistance Abcb1 
UnknownTumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.
Not available
S-EPMC3945416 | biostudies-literature
UnknownRisks and Implications of Multiple Actionable Pathogenic Germline Variants Discovered by Panel-Based Cancer Predisposition Testing.
Not available
S-EPMC12537039 | biostudies-literature
UnknownGenetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.
Not available
S-EPMC6981222 | biostudies-literature
UnknownThe drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells.
Not available
S-EPMC9552188 | biostudies-literature
UnknownDiversity in CO2-Concentrating Mechanisms among Chemolithoautotrophs from the Genera Hydrogenovibrio, Thiomicrorhabdus, and Thiomicrospira, Ubiquitous in Sulfidic Habitats Worldwide.
Not available
S-EPMC6344615 | biostudies-literature
UnknownNivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.
Not available
S-EPMC5719487 | biostudies-literature
UnknownCandidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.
Not available
S-EPMC2947620 | biostudies-literature
UnknownSelinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
Not available
S-EPMC9467680 | biostudies-literature
UnknownLow-Dose Methotrexate for the Prevention of Atherosclerotic Events.
Not available
S-EPMC6587584 | biostudies-literature
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