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MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
TranscriptomicsDefining a developmental path to neural fate by global expression profiling of mouse ESCs and adult NS cells
Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/progenitor cells. This SuperSeries is composed of the following subset Series: GSE4075: Neural induction (Embrioid bodies-Retinoic acid) GSE4076: Neural induction (N2B27 m...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-4082 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential rosette neural stem cell regulators
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in study of neurogenesis and cell replacement therapy. However,...
ORGANISM(S): Macaca mulatta 
2014-07-03 | E-GEOD-53260 | biostudies-arrayexpress
TranscriptomicsCD133/CD140a-Based Isolation of Distinct Human Multipotent Neural Progenitor Cells and Oligodendrocyte Progenitor Cells
The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated t...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-40676 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of mouse cerebral cortical neural progenitor cells
Transcriptome analysis of neural progenitor/stem cells is limited by the lack of a reliable method for cell isolation. We have designed a genetic dual reporter strategy that can allow prospective isolation of cortical neural progenitor cells and their neuronal progeny form the same animals. These ce...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-22946 | biostudies-arrayexpress
TranscriptomicsRapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Stem cell biology has garnered much attention due to its potential to impact human health through disease modeling and cell replacement therapy. This is especially pertinent to myelin-related disorders such as multiple sclerosis and leukodystrophies where restoration of normal oligodendrocyte funct...
ORGANISM(S): Mus musculus 
2011-10-02 | E-GEOD-31562 | biostudies-arrayexpress
TranscriptomicsES, EC, NS, TS, Placenta and Neural induction (N2B27) comaprison
Comparison among ES, EC, TS, NS, differentiated neural cells derived from NS and placenta in addition to ES-N2B27 neural induction. Comparison among ES, EC, TS, NS, differentiated neural cells derived from NS and placenta in addition to ES-N2B27 neural induction.
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-4077 | biostudies-arrayexpress
ProteomicsMina53 demethylates histone 4 arginine 3 asymmetric di-methylation to regulate neural stem/progenitor cell identity
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers－arginine demethylases－remain mysterious. Here we identify Myc-induced nuclear antigen 53 (Mina53), a jumonji C do...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD045247 | Pride
Histone methylation Neural stem/progenitor cells Epigenetics Arginine demethylation Mina53 
TranscriptomicsProspective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting
Sox2 is expressed by neural stem and progenitor cells, and a sox2 enhancer identifies these cells in the forebrains of both fetal and adult transgenic mouse reporters. We found that an adenovirus encoding EGFP placed under the regulatory control of a 0.4 kb sox2 core enhancer selectively identified ...
ORGANISM(S): Homo sapiens 
2011-02-25 | E-GEOD-27505 | biostudies-arrayexpress
TranscriptomicsLong Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recur...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-74356 | biostudies-arrayexpress
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