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ProteomicsNeuroblastoma HLA class I Immunopeptidomics
We surveyed the immunopeptidome of neuroblastoma tumors to identify tumor-specific targets derived from non-mutated self proteins originating from core-regulatory circuit proteins.
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD027182 | Pride
Tumor antigens Neuroblastoma immunopeptidomics Hla class i Phox2b 
ProteomicsCombining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB). Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that trims peptides before loading on M...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055268 | Pride
Mhc Immunotherapy Neuroblastoma Immunopeptidomics Erap 
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