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TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray
Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Ph...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-9619 | biostudies-arrayexpress
TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray
Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Ph...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-9603 | biostudies-arrayexpress
TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
This SuperSeries is composed of the following subset Series: GSE9603: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray GSE9619: Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on ...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9620 | biostudies-arrayexpress
TranscriptomicsFunctional Connection with Cardiac Tissues Confers Maturation Phenotypes in hPSC-Derived PHOX2B::GFP Expressing Sympathetic Neurons
Neurons derived from human pluripotent stem cells (hPSCs) are a remarkable tool for modeling human neural development and diseases. However, it remains largely unknown whether the hPSC-derived neurons can be functionally coupled with their target tissues in vitro, which is essential for understandin...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-80689 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cell line expressing PHOX2B
Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS). One of the master regulator genes for peripheral SNS differentiation, the homeobox transcription factor PHOX2B, is mutated in familiar and sporadic neuroblastomas. Here we report that inducible expression of PH...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-9339 | biostudies-arrayexpress
GenomicsPHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway
PHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway
PRJNA779710 | ENA
UnknownPHOX2B is a suppressor of neuroblastoma metastasis.
Not available
S-EPMC4891146 | biostudies-literature
TranscriptomicsPHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway
Studies have shown that PHOX2B is the first predisposition gene identified in neuroblastoma.To explore PHOX2B-dependent gene regulation, RNA-seq analysis was performed. Compared with the control group, PHOX2B knockdown SK-N-BE(2) cells showed differently expressed genes. We found that PHOX2B activat...
ORGANISM(S): Homo sapiens 
2022-08-29 | GSE188622 | GEO
GenomicsCRISPR/Cas9-MEDIATED PHOX2B FUNCTIONAL KNOCK-OUT IN IMR32 NEUROBLASTOMA CELLS IMPAIRS NEURONAL EXCITABILITY THROUGH DYSREGULATION OF ION CHANNELS GENES
CRISPR/Cas9-MEDIATED PHOX2B FUNCTIONAL KNOCK-OUT IN IMR32 NEUROBLASTOMA CELLS IMPAIRS NEURONAL EXCITABILITY THROUGH DYSREGULATION OF ION CHANNELS GENES
PRJNA1462635 | ENA
TranscriptomicsIdentification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray
Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Ph...
ORGANISM(S): Mus musculus 
2008-06-30 | GSE9619 | GEO
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